CELL MIGRATIONS TO ISOCORTEX IN RAT
CELL MIGRATIONS TO ISOCORTEX IN RAT
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DOI：
10.1002/ar.1091600311
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发表时间：
1968-01-01
影响因子：
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通讯作者：
DAMATO, CJ
中科院分区：
文献类型：
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作者：
HICKS, SP;DAMATO, CJ
细胞，采取了氚标记的胸苷（H-3 T）在不同时期的子宫内和早期的婴儿生活在脑室周围的增殖区，并迁移到形成大鼠的isocortex跟踪放射自显影在一系列的阶段，以表征他们的运动。在任何阶段被标记的细胞很快就会分成几个群体，一些继续增殖，另一些立即迁移，还有一些在迁移之前延迟。移行细胞沿着苍白球纤维的弯曲和倾斜的路径向发育中的皮质移动，其基本计划由早期的丘脑皮质纤维确定。速度为15 ~ 30 [mu]/hr。起源于子宫内第14 ~ 18天的原始神经细胞在约48小时内首先到达皮层，其他人则需要两三天的时间。出生后第19 ~ 21天的迁移一直持续到出生后的一周;然而，当原始细胞接近皮质时，它们分化成年轻的神经元，并垂直地向皮质的外部迁移。第20天标记的细胞的第一个队列在约3天内到达它们的皮质内目的地，最后一个在约10天内到达。等皮质基本上是由内向外形成的。第一个神经胶质细胞注定的isocortex出现在子宫内的第21天。
Cells that took up tritiated thymidine (H-3T) at various periods of intrauterine and early infant life in the periventricular proliferative zone and migrated to form the isocortex in the rat were tracked autoradiographically in series of stages to characterize their movements. Cells labeled at any stage soon separated themselves into cohorts, some continuing to proliferate, other migrating at once, and still others delaying before migrating. Migratory cells moved to the developing cortex along the curved and oblique paths of the pallial fibers, whose basic plan was established by the early thalamocortical fibers. Magnitude of speed was 15 to 30 [mu]/hr. The primitive neural cells that originated on each of the 14th to 18th intrauterine days first reached the cortex in about 48 hr., others took 2 or 3 days longer. Migrations originating on the 19th to 21st days continued into the week after birth; as the primitive cells approached the cortex, however, they differentiated into young neurons, and traveled perpendicularly to its outer part. The first cohort of 20th day labeled cells reached their intracortical destinations in about 3 days, the last in about 10 days. The isocortex was formed essentially from within outward. The first neuroglia destined for the isocortex arose on the 21st intrauterine day.