Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.
Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.
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副氧酶1多态性和缺血性中风风险：系统评价和荟萃分析。
DOI：
10.1097/gim.0b013e3181ee81c6
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Trikalinos TA
中科院分区：
文献类型：
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作者：
Dahabreh IJ;Kitsios GD;Kent DM;Trikalinos TA
对氧磷酶1（PON 1）多态性被认为是冠心病的危险因素，但对缺血性卒中相关表型的遗传关联研究结果尚不确定。我们对已发表的研究进行了荟萃分析，这些研究调查了人类缺血性卒中与两种非同义PON 1多态性rs662（p.Q192R）和rs 854560（p.L55M）之间的关联。我们检索了截至2009年6月30日的多个电子数据库中的合格研究。在主要分析中，我们用随机效应模型计算了基于等位基因的优势比（OR）。在二次分析中，我们还检查了显性和隐性遗传模型，并进行了亚组和敏感性分析。关于rs662，我们确定了22项合格的研究（共7384例病例/11,074例对照），每个G等位基因的汇总OR为1.10（95%置信区间，CI，1.04-1.17），没有证据表明研究间异质性。对于rs 854560，16项合格研究（共5518例病例/8951例对照）得出每个T等位基因的汇总OR为0.97（95%CI，0.90-1.04），同样没有研究间异质性的证据。对于这两种多态性，显性和隐性遗传模型的分析产生了相同的推论等位基因为基础的比较。亚组和敏感性分析显示了相似的结果。与冠状动脉疾病的观察结果一致，PON 1 rs662似乎与缺血性卒中风险的小幅增加相关。
Paraoxonase 1 (PON1) polymorphisms have been implicated as risk factors for coronary artery disease, but the results of genetic association studies on the related phenotype of ischemic stroke are inconclusive. We performed a meta-analysis of published studies investigating the association between ischemic stroke and two non-synonymous PON1 polymorphisms, rs662 (p.Q192R) and rs854560 (p.L55M) in humans. We searched multiple electronic databases through 06/30/2009 for eligible studies. In main analyses we calculated allele-based odds ratios (OR) with random effects models. In secondary analyses we examined dominant and recessive genetic models as well, and performed subgroup and sensitivity analyses. Regarding rs662, we identified 22 eligible studies (total of 7384 cases/11,074 controls), yielding a summary OR of 1.10 per G allele (95% confidence interval, CI, 1.04–1.17) with no evidence of between-study heterogeneity. For rs854560, 16 eligible studies (total of 5518 cases/8951 controls) yielded a summary OR of 0.97 per T allele (95% CI, 0.90–1.04), again with no evidence of between-study heterogeneity. For both polymorphisms, analyses with dominant and recessive genetic models yielded the same inferences as allele-based comparisons. Subgroup and sensitivity analyses showed similar results. In agreement with observations in coronary artery disease, PON1 rs662 appears to be associated with a small increase in the risk of ischemic stroke.