Aldosterone induces contraction of the resistance arteries in man
Aldosterone induces contraction of the resistance arteries in man
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DOI：
10.1016/s0021-9150(02)00363-5
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发表时间：
2003-02-01
期刊：
影响因子：
5.3
通讯作者：
Santiemma, V
中科院分区：
文献类型：
--
作者：
Romagni, P;Rossi, F;Santiemma, V
近年来，醛固酮在体外的非基因组效应非常迅速，体内的证据也有报道。在本研究中，我们研究了醛固酮对人体阻力动脉的快速作用。我们对10名健康男性志愿者进行了一项随机、安慰剂对照、双盲交叉研究。前臂血流量（FBF）的测量使用静脉闭塞体积描记法在两个前臂。在第4分钟给予2.5 pmol/ min的醛固酮，FBF降低（从4.45 +/- 0.03降至3.3 +/- 0.25 ml/100 ml组织），并在第12分钟达到最低点（从4.45 +/- 0.03降至1.6 +/- 0.08 ml/100 ml组织，P < 0.001）。我们的研究记录了醛固酮在人体内对阻力动脉的直接非基因组效应。在生理浓度下醛固酮的快速血管收缩效应为研究这种类固醇在几种疾病中的血管作用开辟了道路，例如高血压，其特征在于外周血管阻力升高。(C)2002年由Elsevier Science爱尔兰有限公司出版。
Very rapid nongenomic effects of aldosterone in vitro have been described in recent years and in vivo evidence has been reported as well. In the present study, we investigated the rapid effect of aldosterone on resistance arteries in vivo in man. We performed a randomized, placebo-controlled, double-blind crossover study on ten healthy male volunteers. Forearm blood flow (FBF) was measured using venous occlusion plethysmography in both forearms. FBF was reduced by administration of aldosterone 2.5 pmol/ min at min 4 (from 4.45 +/- 0.03 to 3.3 +/- 0.25 ml/100 ml tissue) and reached its nadir at min 12 (from 4.45 +/- 0.03 to 1.6 +/- 0.08 ml/100 ml tissue, P < 0.001). Our study documents a direct nongenomic effect of aldosterone on the resistance arteries in vivo in man. The rapid vasoconstrictive effect of aldosterone at physiological concentrations opens the way to investigations on the vascular role of this steroid in several disorders, such as hypertension, characterized by elevated peripheral vascular resistance. (C) 2002 Published by Elsevier Science Ireland Ltd.