NEUROVASCULAR PERMEABILITY AND FIBRIN DEPOSITION IN THE CENTRAL NEURAXIS OF LEWIS RATS WITH CELL-TRANSFERRED EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RELATIONSHIP TO CLINICAL AND HISTOPATHOLOGICAL FEATURES OF THE DISEASE
NEUROVASCULAR PERMEABILITY AND FIBRIN DEPOSITION IN THE CENTRAL NEURAXIS OF LEWIS RATS WITH CELL-TRANSFERRED EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RELATIONSHIP TO CLINICAL AND HISTOPATHOLOGICAL FEATURES OF THE DISEASE
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DOI：
10.1016/0165-5728(93)90024-s
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发表时间：
1993-09-01
影响因子：
3.3
通讯作者：
PATERSON, PY
中科院分区：
文献类型：
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作者：
KOH, CS;GAUSAS, J;PATERSON, PY
双同位素技术检测到血脑屏障（BBB）通透性突然增加，与凝血级联激活的证据相一致，发生在实验性过敏性脑脊髓炎（EAE）临床神经症状出现前1天，并与最初可检测到的细胞浸润相结合。在出现临床症状的第一天观察到血脑屏障通透性最大增加，即临床异常最严重的前 2 天，中枢神经系统 (CNS) 纤维蛋白沉积和血管周围细胞浸润最多的前 1 天。在神经体征完全缓解之前，血脑屏障通透性增加和中枢神经系统血管周围纤维蛋白沉积物恢复到正常水平。然而，在神经体征完全缓解后，仍存在大量中枢神经系统血管周围细胞浸润。这些发现表明，与凝血级联激活相关的血脑屏障通透性增加是实验性过敏性 EAE 免疫效应子活性的最早表现。
Abrupt increases in blood-brain barrier (BBB) permeability were detected by the dual-isotope technique, coinciding with evidence of activation of coagulation cascade, occurred 1 day prior to appearance of clinical neurological signs of experimental allergic encephalomyelitis (EAE) and in conjunction with initial detectable cell infiltration. Maximal increase of BBB permeability was observed on the first day of clinical signs, which was 2 days prior to maximum severity of clinical abnormalities and 1 day in advance of the greatest number of central nervous system (CNS) fibrin deposits and perivascular cellular infiltration. Returning of increased BBB permeability and CNS perivascular fibrin deposits to normal levels was demonstrated prior to complete remission of neurological signs. Considerable CNS perivascular cellular infiltrates, however, lasted after complete remission of neurological signs. These findings indicate that increased permeability of the BBB, in association with activation of the coagulation cascade, is the earliest expressions of immune effector activity of experimental allergic EAE.