UTILITY OF AN ELEVATED PLUS-MAZE FOR THE EVALUATION OF MEMORY IN MICE - EFFECTS OF NOOTROPICS, SCOPOLAMINE AND ELECTROCONVULSIVE SHOCK
UTILITY OF AN ELEVATED PLUS-MAZE FOR THE EVALUATION OF MEMORY IN MICE - EFFECTS OF NOOTROPICS, SCOPOLAMINE AND ELECTROCONVULSIVE SHOCK
复制标题
DOI：
10.1007/bf02253713
复制
发表时间：
1990-01-01
影响因子：
3.4
通讯作者：
KAMEYAMA, T
中科院分区：
文献类型：
--
作者：
ITOH, J;NABESHIMA, T;KAMEYAMA, T
采用由两个开放臂和两个封闭臂组成的高架十字迷宫来评估小鼠的记忆力。十字迷宫中的小鼠从开放臂逃到封闭臂，因为小鼠显然不喜欢开放和高的空间。记录小鼠从张开臂移动到封闭臂所需的时间（转移潜伏期）。以每天一次试验、持续 5 天的速度记录时，第 2 天之后的传输潜伏期明显短于第 1 天。与对照组的转移潜伏期相比，在第一次试验后立即施用电休克（300V，1s）或东莨菪碱（20μg，ICV）的小鼠中，第二天的转移潜伏期显着延长。接受电休克的小鼠中转移潜伏期的延长可以通过阿尼拉西坦（20 mg/kg，PO）预处理而逆转，但他克林和毒扁豆碱则不能逆转。给予东莨菪碱的小鼠中，通过用阿尼拉西坦（10 和 20 mg/kg，PO）、他克林（1 和 3 mg/kg，PO）或毒扁豆碱（0.025-0.2 mg/kg，IP）预处理，可以逆转转移潜伏期的延长。这些结果表明，转移延迟可能是学习和记忆的参数之一。
An elevated plus-maze consisting of two open and two enclosed arms was employed for an evaluation of memory in mice. Mice in the plus-maze escaped from the open arm to the enclosed arm because mice apparently dislike open and high spaces. The time it took for the mice to move from the open arm to the enclosed arm (transfer latency) was recorded. The transfer latency after the 2nd day was significantly shorter than that on the 1st day when it was recorded at a rate of one trial a day for 5 days. The transfer latency on the 2nd day was significantly prolonged in the mice administered electroconvulsive shock (300 V, 1 s) or scopolamine (20 .mu.g, ICV) immediately after the first trial compared to the transfer latency in the control group. The prolongation of transfer latency in the mice administered an electroconvulsive shock was reversed by pretreatment with aniracetam (20 mg/kg, PO), but not tacrine and physostigmine. The prolongation of transfer latency in the mice administered scopolamine was reversed by pretreatment with aniracetam (10 and 20 mg/kg, PO) tacrine (1 and 3 mg/kg, PO), or physostigmine (0.025-0.2 mg/kg, IP). These results suggest that transfer latency may be one of the parameters of learning and memory.