Resistance of Plasmodium falciparum in Tanganyika to pyrimethamine administered at weekly intervals
Resistance of Plasmodium falciparum in Tanganyika to pyrimethamine administered at weekly intervals
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DOI：
10.1016/0035-9203(57)90039-1
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发表时间：
1957-01-01
期刊：
影响因子：
--
通讯作者：
SHUTE, G. T.
中科院分区：
文献类型：
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作者：
CLYDE, D. F.;SHUTE, G. T.
坦噶尼喀省有限地区的人群在实行每周预防治疗后5个月内出现了对乙胺嘧啶抗性为正常菌株8 ~ 15倍的恶性疟原虫。在10个月至一年的时间内，这种免疫或耐药菌株的感染率约为早期情况的80%。这种新菌株在形态上与正常的恶性疟原虫没有区别。耐药菌株似乎正在向邻近地区（半径5英里以内）未经治疗的个体缓慢传播。幸运的是，新菌株尚未显示出对氯胍治疗的耐药性。摘要作者：a.c.沃尔顿
Strains of P. falciparum with 8 to 15 times the resistance to pyrimethamine of normal strains appeared within 5 months after the instituting of weekly prophylactic treatments among the population of limited areas of Tanganyika. Within a period of 10 months to a year, such immune or resistant strains became established at an infective rate of about 80% of the earlier condition. This new strain is not morphologically distinct from normal P. falciparum. The resistant strain seems to be slowly spreading to untreated individuals in the immediate area (up to a 5-mile radius). Fortunately the new strain has not as yet shown resistance to proguanil therapy. || ABSTRACT AUTHORS: A. C. Walton