Limits to sustained energy intake XXIV: impact of suckling behaviour on the body temperatures of lactating female mice.
Limits to sustained energy intake XXIV: impact of suckling behaviour on the body temperatures of lactating female mice.
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DOI：
10.1038/srep25665
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发表时间：
2016-05-09
影响因子：
4.6
通讯作者：
Speakman JR
中科院分区：
文献类型：
--
作者：
Gamo Y;Bernard A;Troup C;Munro F;Derrer K;Jeannesson N;Campbell A;Gray H;Miller J;Dixon J;Mitchell SE;Hambly C;Vaanholt LM;Speakman JR
本研究的目的是探讨哺乳期小鼠高体温(TB)的潜在原因，作为能量摄入的假定限制。特别是，我们探索了后代是否有助于母亲在哺乳时保持体温。26只雌性MF1小鼠通过腹膜内植入的传输器监测结核病和体力活动。此外，在整个哺乳过程中，每分钟对8 h d−1的母亲行为进行评分。养大窝的母亲在窝里哺乳时往往有更高的结核病(P <； 005)，这表明哺乳后代可能影响了热保持。然而，哺乳期间的结核病并不高于其他行为期间的记录。此外，观察期内的最高结核病数未在护理行为期间测量。最后，没有迹象表明，母亲在哺乳期间因结核病的逐渐增加而停止哺乳。整个哺乳期的结核病与每日能量摄入量的增加有关。哺乳期间的慢性体温升高不是由于周围后代的热量保持增加引起的。其他因素，比如牛奶生产或能量摄入的副产品产生的新陈代谢热量，可能是更重要的因素。热量散失极限可能不是仅限于哺乳期的现象。
The objective of this study was to investigate the potential causes of high body temperature (Tb) during lactation in mice as a putative limit on energy intake. In particular we explored whether or not offspring contributed to heat retention in mothers while suckling. Tb and physical activity were monitored in 26 female MF1 mice using intraperitoneally implanted transmitters. In addition, maternal behaviour was scored each minute for 8 h d−1 throughout lactation. Mothers that raised larger litters tended to have higher Tb while nursing inside nests (P < 0.05), suggesting that nursing offspring may have influenced heat retention. However, Tb during nursing was not higher than that recorded during other behaviours. In addition, the highest Tb during the observation period was not measured during nursing behaviour. Finally, there was no indication that mothers discontinued suckling because of a progressive rise in their Tb while suckling. Tb throughout lactation was correlated with daily increases in energy intake. Chronic hyperthermia during lactation was not caused by increased heat retention due to surrounding offspring. Other factors, like metabolic heat produced as a by-product of milk production or energy intake may be more important factors. Heat dissipation limits are probably not a phenomenon restricted to lactation.