Epidemiology of Trichomonas vaginalis and Human Papillomavirus Infection Detected by Real-Time PCR in Flanders
Epidemiology of Trichomonas vaginalis and Human Papillomavirus Infection Detected by Real-Time PCR in Flanders
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DOI：
10.1159/000314017
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发表时间：
2010-01-01
影响因子：
2.1
通讯作者：
Donders, Gilbert G. G.
中科院分区：
文献类型：
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作者：
Depuydt, Christophe E.;Leuridan, Elke;Donders, Gilbert G. G.
目的探讨弗兰德斯地区14-97岁妇女宫颈液基细胞学标本中人乳头瘤病毒（HPV）感染与阴道毛滴虫（TV）感染的关系（n = 62 636），安特卫普地区的专业性工作者（n = 308），所有弗兰德斯居民（比利时北部）和参加宫颈癌筛查，评估TV和HPV的存在。方法在2008年的7个月期间，62，评估了944份连续液基细胞学宫颈癌筛查样本的细胞学异常。所有样本均通过实时定量PCR检测TV以及低风险HPV（IrHPV）类型的存在6 11，53，6 HPV（3和67型）和高危型HPV（hrHPV）16、18、31、33、35、39、45、51、52、56、58、59和68型之间的相关性，结果弗兰德斯地区总人群TV患病率为0 37%，41-45岁妇女的HPV感染率最高（0.53%），15.1%的宫颈标本检出HPV，21- 45岁妇女的HPV感染率最高，25岁时HPV感染者1V感染率为26.8%，高于非HPV感染者（0.61vs.0.33%，p < 0. 0001）在疑似外国来源的妇女中，TV患病率是可能本地人群的4倍（116vs0.29%，p <0.0001）与其他女性相比，从事性工作的女性感染HPV和TV的风险增加（OR 8 6 95% CI 4 4-16 9 p < 0 0 0 0 1），城市地区TV患病率高于农村地区结论弗兰德斯地区TV的患病率低于文献报道，而HPV感染的患病率与欧洲其他检测系统相似的国家相似。TV和HPV均为性传播感染，但我们的流行病学数据表明，在弗兰德斯，HPV和TV的流行病学是不同的。在年轻妇女中发现HPV流行率最高，而TV在老年妇女中更常见。尽管社会的一些流行病学特点，例如滥交和从海外国家输入，可能解释流行病学的差异，确切的原因仍有待进一步研究中阐明版权所有（C）2010 S Karger AG巴塞尔
Objective The goal of this cross-sectional laboratory-based study is to investigate the association between Trichomonas vaginalis (TV) and human papillomavirus (HPV) infections in cervical samples in Flanders Setting Liquid-based cervical cytology samples from unselected women, covering a population of 14-97 year, of age (n = 62,636), and from professional sex workers of the region of Antwerp (n = 308), all residents of Flanders (North Belgium) and participating in cervical cancer screening, were assessed for the presence of TV and HPV Methods During 7 months in 2008, 62,944 consecutive liquid-based cytology cervical cancer screening samples were assessed for cytological abnormalities All samples were tested by real-time quantitative PCR for the presence of TV as well as for low-risk HPV (IrHPV) types 6 11, 53, 6(3 and 67, and high-risk HPV (hrHPV) types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68 Association between TV and HPV infections with age, geographic area and occurrence of cytologic le,,ions were investigated Results The overall prevalence of TV in the general population in Flanders was 0 37%, with the highest prevalence in women aged 41-45 years (0 53%) HPV was detected in 15 1% of cervical samples and peaked in younger women of ages 21-25 years (26 8%) The prevalence of 1V was higher in women with HPV infections as compared to women without HPV (0 61 vs 0 33%, p < 0 0001) In women of suggestive foreign origin, TV prevalence was 4 times higher than in the probably autochthonous population (116 vs 0 29%, p < 0 0001) Working in the sex industry had an increased risk of both HPV and TV when compared to other women (OR 8 6 95% CI 4 4-16 9 p < 0 0001) and a higher rate of TV was also observed in urban regions, compared to rural areas (OR 1 7 (1 3-2 2), p = 0 0002) Conclusion The prevalence of TV in Flanders is lower compared to data from the literature, whereas the prevalence of HPV infection is similar to that reported in other European countries with similar test systems Both TV and HPV are sexually transmitted infections, but our prevalence data suggest that the epidemiology of HPV and TV are different in Flanders Highest HPV prevalence is found in young women whereas TV is more frequent in older women Although some epidemiological peculiarities of the society, such as promiscuity and import from overseas countries, can possibly account for the differences in epidemiology, the exact reasons remain to be elucidated in further studies Copyright (C) 2010 S Karger AG Basel