Herpesvirus and the Lucké tumor.
Herpesvirus and the Lucké tumor.
复制标题
疱疹病毒和幸运肿瘤。
作者：
A. Granoff
Summary Rana pipiens is host to a renal adenocarcinoma (Lucke tumor) that occurs with high frequency in a wild heterogeneous animal population. There is a relationship between temperature and the presence or absence of herpesvirus in tumor cells. Tumor cells of frogs either in hibernation or maintained at low temperature (4 to 9°) in the laboratory contain intranuclear inclusion bodies (Cowdry type A) and herpesvirus. In contrast, neither inclusions nor virus are found in tumor cells of frogs captured in the spring or summer or maintained in the laboratory at 20 to 25°. Lucke tumors can be induced in developing frog embryos by cell-free tumor extracts containing herpesvirus or by ascitic fluid containing this virus. A number of cell cultures (from insect to mammalian) have been tested for susceptibility to the Lucke tumor herpesvirus, but none has been found that will support multiplication of the virus. A number of other viruses have been isolated, including a herpesvirus distinct from the one seen in tumor cells, but none of them induce tumors.
