Brain β-Endorphin during Pregnancy, Parturition, and the Postpartum Period*
Brain β-Endorphin during Pregnancy, Parturition, and the Postpartum Period*
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怀孕、分娩和产后期间的大脑 β-内啡肽*
DOI：
10.1210/endo-113-5-1664
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发表时间：
1983
期刊：
影响因子：
4.8
通讯作者：
A. Frantz
中科院分区：
文献类型：
--
作者：
S. Wardlaw;A. Frantz
Brain β-endorphin (β-EP) was measured in the rat during pregnancy, parturition, and the postpartum period. β-EP increased in the hypothalamus, midbrain, and amygdala during gestation and remained elevated through delivery until 1—2 days postpartum. The concentration of β-EP increased in the hypothalamus from 31.8 ± 1.4 (±SE) ng/mg protein in nonpregnant controls to41.4 ± 1.8 and 39.2 ± 1.9 during early (8—10 days) and late (18—20 days) pregnancy, respectively, and in the midbrain from 3.20 ± 0.17 to 5.21 ± 0.30 and 5.25 ± 0.64 ng/mg protein (P < 0.01). In another experiment, the brain content of β-EP expressed as nanograms per region, increased from 12.6 ± 0.29 to 14.7 ± 0.33 in the hypothalamus, from 4.09 ± 0.44 to 6.03 ± 0.34 inthe midbrain, and from 0.93 ± 0.11 to 1.32 ± 0.06 ng in the amygdala at 16—17 days of gestation compared with that in nonpregnant controls (P < 0.01). When hypothalamic β-EP was measured 1 week postpartum in lactating and nonlactating rats, a significant decline in the β-EP conce...
