Status of endothelial dependent vasodilation in patients with hyperuricemia
Status of endothelial dependent vasodilation in patients with hyperuricemia
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DOI：
10.1016/j.amjcard.2005.07.068
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发表时间：
2005-12-01
影响因子：
2.8
通讯作者：
Somers, VK
中科院分区：
文献类型：
--
作者：
Kato, M;Hisatome, I;Somers, VK
高尿酸血症与心血管疾病风险增加和死亡率增加有关。然而，将血清尿酸升高与心血管疾病联系起来的生物学机制尚不确定。本研究验证了血清尿酸升高与无明显心血管疾病的高尿酸血症患者内皮功能受损相关的假设。研究了17例男性高尿酸血症患者（平均年龄42 ± 4岁）和9例对照受试者（平均年龄45 ± 5岁）。所有受试者均为非吸烟者。所有患者从未接受过高尿酸血症治疗，未服用任何药物，且无任何其他已知疾病。通过超声测量血流介导的血管扩张来评价内皮功能。高尿酸血症患者（4.0 +/- 0.7%）与对照组（6.4 +/- 0.8%）相比，血流介导的舒张功能显著受损（p = 0.044）。血流介导的舒张功能与尿酸水平呈负相关（r =-0.4，p = 0.05）。高尿酸血症患者中硝酸盐诱导的扩张为12.3 +/- 1.0%，对照组为11.8 +/- 2.3%（p = 0.82）。即使没有任何明显的心血管疾病，高尿酸血症患者也存在内皮依赖性血管舒张功能受损。血清尿酸升高本身可能是内皮功能障碍的一个新的危险因素。(c)2005年爱思唯尔公司All rights reserved.
Hyperuricemia has been associated with an increased risk for cardiovascular disease and increased mortality. However, the biologic mechanisms that link elevated serum uric acid to cardiovascular disease are uncertain. This study tested the hypothesis that elevated serum uric acid is associated with impaired endothelial function in hyperuricemic patients without any overt cardiovascular disease. Seventeen male patients with hyperuricemia (mean age 42 +/- 4 years) and 9 control subjects (mean age 45 +/- 5 years) were studied. All subjects Were nonsmokers. All patients had never been treated for hyperuricemia, were on no medications, and were free of any other known diseases. Endothelial function was evaluated by flow-mediated dilation measured by ultrasound. Flow-mediated dilation was significantly impaired in patients with hyperuricemia (4.0 +/- 0.7%) compared with control subjects (6.4 +/- 0.8%) (p = 0.044). Flow-mediated dilation correlated inversely with uric acid levels (r = -0.4, p = 0.05). Nitrate-induced dilation was 12.3 +/- 1.0% in patients with hyperuricemia and 11.8 +/- 2.3% in control subjects (p = 0.82). Impaired endothelial-dependent vasodilation is present in hyperuricemic patients even in the absence of any overt cardiovascular disease. The elevated serum uric acid, per se, may constitute a novel risk factor for endothelial dysfunction. (c) 2005 Elsevier Inc. All rights reserved.