Computational analysis of effects of clot length on Acute ischemic stroke recanalization under different cyclic aspiration loading conditions.
Computational analysis of effects of clot length on Acute ischemic stroke recanalization under different cyclic aspiration loading conditions.
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不同循环抽吸负荷条件下凝块长度对急性缺血性卒中再通影响的计算分析。
DOI：
10.1002/cnm.3667
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发表时间：
2023-02
影响因子：
2.1
通讯作者：
Costanzo, Francesco
中科院分区：
文献类型：
--
作者：
Patki, Priyanka;Simon, Scott;Manning, Keefe B.;Costanzo, Francesco
急性缺血性中风是世界范围内第二大死亡原因，是由血栓阻塞脑动脉引起的。使用抽吸导管的循环抽吸的应用是用于去除沉积的凝块的当前疗法。在这项研究中，我们进行有限元模拟，以分析长凝块的变形，具有2-10的长度与半径比，这对应于凝块长度为2.85-14.25 mm，在10-50 mmHg的峰-峰循环抽吸压力下，频率为0.5，1和2 Hz。我们的计算系统包括一个非线性粘弹性固体凝块，超弹性动脉，和一个非线性粘弹性粘性区，后者模拟凝块动脉界面。我们观察到，无论循环抽吸负载条件如何，长度半径比约大于2的凝块在轴向和远端之间的某处与动脉内表面分离。凝块内的应力分布显示凝块内部存在较大的拉伸应力，表明凝块可能同时破碎。因此，本研究向我们展示了循环抽吸期间凝块中同时存在的各种失效机制。类似地，动脉内的应力分布意味着在施加抽吸压力的端部附近动脉壁的内皮损伤的可能性。该框架为进一步研究凝块断裂和粘附特性提供了基础。
Acute ischemic stroke, the second leading cause of death worldwide, results from occlusion of a cerebral artery by a blood clot. Application of cyclic aspiration using an aspiration catheter is a current therapy for the removal of lodged clots. In this study, we perform finite element simulations to analyze deformation of long clots, having length to radius ratio of 2–10, which corresponds to clot–length of 2.85–14.25 mm, under peak-to-peak cyclic aspiration pressures of 10–50 mmHg, and frequencies of 0.5, 1, and 2 Hz. Our computational system comprises of a nonlinear viscoelastic solid clot, a hyperelastic artery, and a nonlinear viscoelastic cohesive zone, the latter modeling the clot–artery interface. We observe that clots having length-to-radius ratio approximately greater than two separate from the inner arterial surface somewhere between the axial and distal ends, irrespective of the cyclic aspiration loading conditions. The stress distribution within the clot shows large tensile stresses in the clot interior, indicating the possibility of simultaneous fragmentation of the clot. Thus, this study shows us the various failure mechanisms simultaneously present in the clot during cyclic aspiration. Similarly, the stress distribution within the artery implies a possibility of endothelial damage to the arterial wall near the end where the aspiration pressure is applied. This framework provides a foundation for further investigation to clot fracture and adhesion characterization.
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影响因子：
4.8
作者：
Fargen, Kyle M.;Arthur, Adam S.;Turk, Aquilla S.
通讯作者：
Turk, Aquilla S.
影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
3.5
作者：
Kaesmacher, J.;Boeckh-Behrens, T.;Huber, T.
通讯作者：
Huber, T.
影响因子：
2.7
作者：
Hindmarsh, AC;Brown, PN;Woodward, CS
通讯作者：
Woodward, CS
影响因子：
8.3
作者：
Langer, David;Alexander, Michael;Gomes, Joao
通讯作者：
Gomes, Joao