Quantifying the RSV immunity debt following COVID-19: a public health matter.
Quantifying the RSV immunity debt following COVID-19: a public health matter.
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量化COVID-19后的RSV免疫债：公共卫生问题。
DOI：
10.1016/s1473-3099(22)00544-8
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发表时间：
2023-01
影响因子：
56.3
通讯作者：
Bont, Louis J.
中科院分区：
文献类型：
--
作者：
Billard, Marie-Noelle;Bont, Louis J.
呼吸道合胞病毒（RSV）是5岁以下儿童下呼吸道感染的最常见原因。2019年，一项荟萃分析估计，RSV每年与3300万次急性下呼吸道感染发作和360万次急性下呼吸道感染住院相关。1仅在英格兰，2007年至2012年期间平均每年观察到33561例RSV相关住院。2在COVID-19大流行之前，RSV在英格兰等温带国家具有高度季节性。3在2020年3月实施非药物干预措施以减缓SARS-CoV-2传播（例如物理距离和学校关闭）后不久，RSV活性下降。4随后，多个国家报告了在一个安静的冬季之后的反季节RSV复发。5由于驱动因素或RSV季节性以及RSV每年重新接种的机制尚未完全了解，6，7估计非药物干预对RSV的影响是公共卫生决策者规划监测活动和医院准备的重要工具。
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in children younger than 5 years. In 2019, a meta-analysis estimated that RSV was associated with 33 million acute lower respiratory infection episodes and 3· 6 million hospitalisations for acute lower respiratory infection annually. 1 In England alone, an average of 33 561 annual RSV-associated hospitalisations were observed between 2007 and 2012. 2 Before the COVID-19 pandemic, RSV was highly seasonal in temperate countries like England. 3 RSV activity dropped shortly after the implementation of non-pharmaceutical interventions to slow the spread of SARS-CoV-2 (eg, physical distancing and school closures) in March, 2020. 4 Subsequently, multiple countries reported out-of-season RSV resurgences after a silent winter season. 5 As the drivers or RSV seasonality and the mechanisms by which RSV is re-seeded annually are not fully understood, 6, 7 estimating the impact of non-pharmaceutical interventions on RSV is an important tool for public health decision makers to plan surveillance activities and hospital preparedness.