The decidual gamma-delta T cells up-regulate the biological functions of trophoblasts via IL-10 secretion in early human pregnancy
The decidual gamma-delta T cells up-regulate the biological functions of trophoblasts via IL-10 secretion in early human pregnancy
复制标题
妊娠早期蜕膜 γ-δ T 细胞通过分泌 IL-10 上调滋养细胞的生物学功能
DOI：
10.1016/j.clim.2011.07.008
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发表时间：
2011-12-01
影响因子：
8.6
通讯作者：
Jin, Li-Ping
中科院分区：
文献类型：
--
作者：
Fan, Deng-Xuan;Duan, Jie;Jin, Li-Ping
蜕膜γ δ T细胞在人类妊娠早期的功能尚未完全了解。本研究旨在探讨人早孕期蜕膜γ δ T细胞在滋养层细胞增殖和侵袭中的作用。结果显示，蜕膜γ δ T细胞是一个CD 4（-）和CD 8（-）亚群，其数量在蜕膜或外周血中显著增加。在蜕膜γ δ T细胞中合成的浓度递减的主要细胞因子为：IL-10 > TGF-β> TNF-α>= IFN-γ，产生很少的IL-2或IL-4。蜕膜γ δ T细胞促进滋养层细胞增殖和侵袭，并通过分泌IL-10抑制滋养层细胞凋亡。提示人蜕膜γ δ T细胞可能在母胎界面Th 2细胞偏向和胎盘的发育过程中发挥重要作用，有利于孕早期母体对胎儿的免疫耐受。(C)2011 Elsevier Inc. All rights reserved.
The functions of decidual gamma delta T cells in early human pregnancy are not fully understood. The present study was undertaken to characterize the action of decidual gamma delta T cells, and analyze their regulatory roles in proliferation and invasion of trophoblasts in early human pregnancy. It was revealed that decidual gamma delta T cells were a CD4(-) and CD8(-) subset whose numbers increased significantly in either the decidua or peripheral blood. The main cytokines synthesized in decidual gamma delta T cells in decreasing concentration were; IL-10 > TGF-beta > TNF-alpha >= IFN-gamma, with little IL-2 or IL-4 being produced. Decidual gamma delta T cells promoted trophoblast proliferation and invasion, and suppressed trophoblast apoptosis through IL-10 secretion in co-culture. These results suggest that gamma delta T cells in human decidua might play an important role in the Th2 bias at maternal-fetal interface and in the development and progression of the placenta, which is beneficial to maternal immunotolerance toward the fetus in early human pregnancy. (C) 2011 Elsevier Inc. All rights reserved.