Direct evidence for a bone marrow origin of the alveolar macrophage in man.
Direct evidence for a bone marrow origin of the alveolar macrophage in man.
复制标题
人类肺泡巨噬细胞起源于骨髓的直接证据。
DOI：
10.1126/science.775638
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发表时间：
1976
期刊：
影响因子：
56.9
通讯作者：
D. Golde
中科院分区：
文献类型：
--
作者：
Thomas Ed;Ramberg Re;G. Sale;RS Sparkes;D. Golde
肺泡巨噬细胞来自23名因血液病接受骨髓移植的患者。通过荧光显微镜证实了雄性来源的巨噬细胞中存在Y体。在接受异性骨髓供体的患者中，肺泡巨噬细胞显示为供体来源。宿主巨噬细胞随时间的消失表明在该条件下的寿命约为81天。
Alveolar macrophages were obtained from 23 patients who had received marrow transplants for hematologic disorders. The presence of a Y body in macrophages of male origin was demonstrated by fluorescence microscopy. In those patients with a marrow donor of opposite sex the alveolar macrophages were shown to be of donor origin. The disappearance with time of host macrophages indicates a life-span, under the conditions, of approximately 81 days.