Mosaic autosomal trisomy in cultures from spontaneous abortions.
Mosaic autosomal trisomy in cultures from spontaneous abortions.
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自然流产培养物中的马赛克常染色体三体性。
DOI：
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发表时间：
1978
影响因子：
9.8
通讯作者：
Z. Stein
中科院分区：
文献类型：
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作者：
D. Warburton;C. Yu;J. Kline;Z. Stein
在连续的592例核型分析的自然流产中，103例常染色体三体中有10例为嵌合体，同时还存在一个正常细胞系。嵌合体的发生率（10%）远高于唐氏综合征的报道，但与羊水培养和人工流产的报道相似。这种差异最可能的解释是（1）以前低估了活产的镶嵌现象或（2）镶嵌现象通常仅限于胚外胎儿组织。
In a consecutive series of 592 karyotyped spontaneous abortions, ten of 103 autosomal trisomies were mosaic, with a normal cell line also present. The frequency of mosaicism (10%) is much higher than that reported in Down syndrome, but similar to that reported in amniotic fluid cultures and in induced abortions. The most likely explanations for this discrepancy are (1) previous underestimation of mosaicism in live births or (2) mosaicism which is often restricted to extraembryonic fetal tissue.