The acoustic cough monitoring and manometric profile of cough and throat clearing
The acoustic cough monitoring and manometric profile of cough and throat clearing
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DOI：
10.1111/dote.12038
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发表时间：
2014-01-01
影响因子：
2.6
通讯作者：
Pandolfino, J. E.
中科院分区：
文献类型：
--
作者：
Xiao, Y.;Carson, D.;Pandolfino, J. E.
咳嗽和清咽可能很难区分时，试图检测他们的声学或测压。本研究的目的是评估声学监测检测咳嗽和清咽的准确性，并确定这两种症状是否存在食管压力地形图上的不同测压曲线。10名无症状志愿者（7名女性，平均年龄31.1岁）接受培训，在同时进行声学监测和高分辨率测压期间，以随机顺序每6分钟模拟咳嗽和清咽。自动声学分析的准确性和两个盲审查进行了比较。使用30 mmHg等压轮廓评估事件模式和压力变化持续时间。根据方案，发生了50起咳嗽和50起清咽事件。自动声学分析对咳嗽的敏感性和特异性分别为84%和50%，而使用声音的盲法分析的敏感性和特异性分别为94%和92%。在定性结果方面，咳嗽和清咽的测压曲线相似;然而，与清咽相比，咳嗽与更大数量的重复加压和更有力的上食管括约肌收缩相关。声学分析软件检测咳嗽的灵敏度中等，特异性较差。压力地形图中的咳嗽和清咽特征显示了类似的加压定性模式，具有更剧烈的压力变化和更高的咳嗽重复加压率。
Cough and throat clearing might be difficult to differentiate when trying to detect them acoustically or manometrically. The aim of this study was to assess the accuracy of acoustic monitoring for detecting cough and throat clearing, and to also determine whether these two symptoms present with different manometric profiles on esophageal pressure topography. Ten asymptomatic volunteers (seven females, mean age 31.1) were trained to simulate cough and throat clearing in a randomized order every 6 minutes during simultaneous acoustic monitoring and high-resolution manometry. The accuracy of automated acoustic analysis and two blinded reviewers were compared. The pattern of the events and the duration of the pressure changes were assessed using the 30mmHg isobaric contour. There were 50 cough and 50 throat-clearing events according to the protocol. The sensitivity and specificity of automated acoustic analysis was 84% and 50% for cough, while the blinded analysis using sound revealed a sensitivity and specificity of 94% and 92%. The manometric profile of both cough and throat clearing was similar in terms of qualitative findings; however, cough was associated with a greater number of repetitive pressurizations and a more vigorous upper esophageal sphincter contraction compared with throat clearing. The acoustic analysis software has a moderate sensitivity and poor specificity to detect cough. The profile of cough and throat clearing in pressure topography revealed a similar qualitative pattern of pressurization with more vigorous pressure changes and a greater rate of repetitive pressurizations in cough.