Exosomes Generated From iPSC-Derivatives: New Direction for Stem Cell Therapy in Human Heart Diseases.
Exosomes Generated From iPSC-Derivatives: New Direction for Stem Cell Therapy in Human Heart Diseases.
复制标题
IPSC衍生物产生的外泌体：人类心脏病中干细胞疗法的新方向。
DOI：
10.1161/circresaha.116.309307
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发表时间：
2017-01-20
影响因子：
20.1
通讯作者：
Yang PC
中科院分区：
文献类型：
--
作者：
Jung JH;Fu X;Yang PC
心血管疾病（CVD）是现代社会的主要死亡原因。成人心脏先天性缺乏修复和再生缺血损伤心肌的能力。对心脏组织修复过程的有限了解阻碍了有效治疗CVD（如缺血性心肌病）的治疗方案的开发。近年来，诱导性多能干细胞（induced pluripotent stem cells，iPSC）和iPSC衍生心肌细胞（iCM）的迅速出现，为心脏补充功能性细胞提供了宝贵的机会。iPSC衍生细胞的治疗效果已经在许多临床前研究中进行了研究。然而，iPSC衍生的细胞治疗的潜在机制仍不清楚，并且众所周知iCM的有限植入。其机制的一个方面是移植细胞的旁分泌效应。从iCM分泌的微囊泡如外来体通过转移内源性分子以通过调节凋亡、炎症、纤维化和血管生成来挽救受损的邻近细胞而发挥保护作用。在这篇综述中，我们将重点介绍iPSC衍生物外泌体的最新进展，并讨论其在治疗CVD中的治疗潜力。
Cardiovascular disease (CVD) is the leading cause of death in modern society. The adult heart innately lacks the capacity to repair and regenerate the damaged myocardium from ischemic injury. Limited understanding of cardiac tissue repair process hampers the development of effective therapeutic solutions to treat CVD such as ischemic cardiomyopathy. In recent years, rapid emergence of induced pluripotent stem cells (iPSC) and iPSC-derived cardiomyocytes (iCM) presents a valuable opportunity to replenish the functional cells to the heart. The therapeutic effects of iPSC-derived cells have been investigated in many preclinical studies. However, the underlying mechanisms of iPSC-derived cell therapy are still unclear and limited engraftment of iCMs are well known. One facet of their mechanism is the paracrine effect of the transplanted cells. Microvesicles such as exosomes secreted from the iCMs exert protective effects by transfering the endogenous molecules to salvage the injured neighboring cells by regulating apoptosis, inflammation, fibrosis and angiogenesis. In this review, we will focus on the current advances in the exosomes from iPSC-derivatives and discuss their therapeutic potential in the treatment of CVD.