Maternal immune activation in nonhuman primates alters social attention in juvenile offspring.
Maternal immune activation in nonhuman primates alters social attention in juvenile offspring.
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DOI：
10.1016/j.biopsych.2014.07.035
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发表时间：
2015-05-01
影响因子：
10.6
通讯作者：
Bauman MD
中科院分区：
文献类型：
--
作者：
Machado CJ;Whitaker AM;Smith SE;Patterson PH;Bauman MD
怀孕期间的疾病与后代神经发育障碍的风险增加有关。啮齿动物模型在建立因果关系和确定幼鼠产前暴露于母体免疫激活（MIA）的大脑和行为发育改变的机制方面发挥了关键作用。我们最近开发了一种新的非人类灵长类动物模型，以弥合人类流行病学研究和啮齿动物产前免疫挑战模型之间的差距。我们的初步结果表明，恒河猴在怀孕期间给予病毒模拟合成双链RNA（多肌苷：用聚赖氨酸稳定的多胞酸），会产生具有异常重复行为、改变沟通和非典型社会互动的后代。我们利用非侵入性红外眼动追踪技术进一步评估了早期妊娠期暴露于mia的后代（n = 4）和对照动物（n = 4）的社会处理能力。作为青少年，MIA的后代在社会关注的几个方面与对照动物不同，特别是当看到描绘恐惧鬼脸的猕猴面部表情时。与对照动物相比，MIA后代注视眼睛的潜伏期更长，注视眼睛的时间更少，注视恐惧鬼脸图像的眼睛的总时间也更少。在恒河猴模型中，在妊娠晚期暴露于MIA会导致对显著社会信息的异常凝视模式。非侵入性眼动追踪的使用将啮齿动物MIA模型的发现扩展到更像人类的行为，类似于自闭症谱系障碍和精神分裂症。
Sickness during pregnancy is associated with an increased risk of offspring neurodevelopmental disorders. Rodent models have played a critical role in establishing causal relationships and identifying mechanisms of altered brain and behavior development in pups prenatally exposed to maternal immune activation (MIA). We recently developed a novel nonhuman primate model to bridge the gap between human epidemiological studies and rodent models of prenatal immune challenge. Our initial results demonstrated that rhesus monkeys given the viral mimic synthetic double-stranded RNA (polyinosinic:polycytidylic acid stabilized with poly-l-lysine) during pregnancy produce offspring with abnormal repetitive behaviors, altered communication, and atypical social interactions. We utilized noninvasive infrared eye tracking to further evaluate social processing capabilities in a subset of the first trimester MIA-exposed offspring (n = 4) and control animals (n = 4) from our previous study. As juveniles, the MIA offspring differed from control animals on several measures of social attention, particularly when viewing macaque faces depicting the fear grimace facial expression. Compared with control animals, MIA offspring had a longer latency before fixating on the eyes, had fewer fixations directed at the eyes, and spent less total time fixating on the eyes of the fear grimace images. In the rhesus monkey model, exposure to MIA at the end of the first trimester results in abnormal gaze patterns to salient social information. The use of noninvasive eye tracking extends the findings from rodent MIA models to more human-like behaviors resembling those in both autism spectrum disorder and schizophrenia.
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DOI：
10.1073/pnas.1301213110
发表时间：
2013-06-18
影响因子：
11.1
作者：
Chang, Steve W. C.;Brent, Lauren J. N.;Platt, Michael L.
通讯作者：
Platt, Michael L.
影响因子：
2
作者：
Chudleigh, Catherine;Naismith, Sharon L.;Hickie, Ian B.
通讯作者：
Hickie, Ian B.
影响因子：
2
作者：
Amminger, G. Paul;Schaefer, Miriam R.;Nelson, Barnaby
通讯作者：
Nelson, Barnaby
DOI：
10.1084/jem.20111171
发表时间：
2011-11-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Caskey M;Lefebvre F;Filali-Mouhim A;Cameron MJ;Goulet JP;Haddad EK;Breton G;Trumpfheller C;Pollak S;Shimeliovich I;Duque-Alarcon A;Pan L;Nelkenbaum A;Salazar AM;Schlesinger SJ;Steinman RM;Sékaly RP
通讯作者：
Sékaly RP
影响因子：
2.6
作者：
Adolphs, R;Tranel, D;Damasio, AR
通讯作者：
Damasio, AR