Association of Serum Uric Acid With Retinal Capillary Plexus.
Association of Serum Uric Acid With Retinal Capillary Plexus.
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血清尿酸与视网膜毛细血管丛的关系
DOI：
10.3389/fendo.2022.855430
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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作者：
使用光学相干断层扫描血管造影 (OCTA) 确定血清尿酸 (SUA) 与视网膜毛细血管丛 (RCP) 之间的关联。这项横断面研究评估了 2019 年 8 月至 2020 年 1 月从冀东社区（中国河北省唐山市）招募的参与者的数据。所有参与者都完成了详细的人体测量、实验室测试和全面的眼科检查。我们使用 OCTA 评估了 RCP 中的血管密度。在调整混杂因素后，我们使用多变量分析来评估 SUA 和 RCP 之间的性别特异性关联。本研究共有 2730 名参与者。参与者的平均年龄为 44.0 ± 11.6 岁，其中 1,463 名 (53.6%) 为女性。与最低 SUA 四分位数相比，第二至第四 SUA 四分位数的浅表 RCP 血管密度的多变量 β 和 95% 置信区间 (CI) 分别为 -0.27 (-0.56 – 0.03)、-0.30 (-0.60 – 0.01) 和 -0.46 (-0.78 – -0.14)（趋势 P = 0.007）男人。男性中较高的 SUA 水平与较低的 RCP 血管密度显着相关。我们的研究结果为高 SUA 水平对视网膜微血管系统的有害影响提供了证据，并暗示调节 SUA 以防止微血管交替的重要性，特别是对于男性而言。
To determine the association between serum uric acid (SUA) and the retinal capillary plexus (RCP) using optical coherence tomography angiography (OCTA). This cross-sectional study evaluated data from August 2019 to January 2020 from participants recruited from the Jidong community (Tangshan, Hebei, China). All participants completed detailed anthropometrical measurements, laboratory tests and comprehensive ophthalmic examinations. We assessed the vessel density in RCP using OCTA. We used multivariable analysis to evaluate the sex-specific association between SUA and RCP after adjusting for confounders. A total of 2730 participants were included in this study. The mean age of the participants was 44.0 ± 11.6 years, and 1463 (53.6%) were women. The multivariable βs and 95% confidence intervals (CIs) of superficial RCP vessel density in the second through fourth SUA quartiles compared with the lowest SUA quartiles were -0.27 (-0.56 – 0.03), -0.30 (-0.60 – 0.01), and -0.46 (-0.78 – -0.14) (P for trend = 0.007) in men. Higher SUA levels were significantly associated with lower RCP vessel density in men. Our findings provide evidence for the detrimental effect of high SUA levels on the retinal microvasculature and imply the importance of modulating SUA to prevent the microvascular alternation especially for men.