Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation
Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation
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DOI：
10.1039/c0sm01237h
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发表时间：
2011-01-01
期刊：
影响因子：
3.4
通讯作者：
Perrier, Sebastien
中科院分区：
文献类型：
--
作者：
Kakwere, Hamilton;Payne, Richard J.;Perrier, Sebastien
Water soluble poly(hydroxyethyl acrylate) [P(HEA)] polymers were successfully conjugated to an azide functionalized beta-sheet forming peptide (P-11-2) to form macromolecular chimeras using Cu(I) catalyzed azide-alkyne cycloaddition ('click') chemistry. We found that the beta-sheet formation and hence fibrillization tendency of P-11-2 was severely diminished by P(HEA) conjugation. Moreover chimeras were observed to inhibit fibrillization when added to a pure b-sheet forming peptide.
