Validation and comparative assessment of low anterior resection syndrome questionnaires in Greek rectal cancer patients
Validation and comparative assessment of low anterior resection syndrome questionnaires in Greek rectal cancer patients
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DOI：
10.20524/aog.2019.0350
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发表时间：
2019-01-01
影响因子：
2.2
通讯作者：
Theodoropoulos, George
中科院分区：
文献类型：
--
作者：
Liapi, Artemis;Mavrantonis, Constantine;Theodoropoulos, George
背景 我们的研究验证了希腊直肠癌患者的低位前切除综合征 (LARS) 评分问卷、结直肠功能结果 (COREFO) 问卷和纪念斯隆-凯特琳癌症中心肠功能仪 (MSKCC-BFI)。 方法 对 LARS、COREFO 和 MSKCC-BFI 问卷的内部一致性、重复性、结构和判别效度进行评估。通过与欧洲癌症研究与治疗组织（EORTC）QLQ-C30和QLQ-CR29域的相关性来评估收敛效度。结果问卷子量表的内部一致性令人满意（Cronbach's a>0.6）。重复性测试显示出极高的再现性（组内相关系数>0.9）。 3份问卷的总分与每个问题之间存在高度正相关（rho>0.5），表明其构建有效。通过与 EORTC QLQ-C30 和 CR29 的可比较领域的相关性，所有调查问卷都表现出良好的收敛效度。 LARS、COREFO、MSKCC-BFI 评分与肿瘤距离和临时造口之间存在统计学显着相关性 (P
Background Our study validated the low anterior resection syndrome (LARS) score questionnaire, the colorectal functional outcome (COREFO) questionnaire, and the Memorial Sloan-Kettering Cancer Center bowel function instrument (MSKCC-BFI) in Greek rectal cancer patients.Methods Internal consistency, repeatability, construct and discriminant validity were evaluated for LARS, COREFO, and MSKCC-BFI questionnaires. The convergent validity was assessed by correlations with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-CR29 domains.Results The internal consistency of the questionnaire's subscales was satisfactory (Cronbach's a>0.6). The repeatability test showed extremely high reproducibility (intraclass correlation coefficient >0.9). High positive correlation was detected between the 3 questionnaires' total scores and each of their questions (rho>0.5), indicating their valid construction. All questionnaires demonstrated a good convergent validity through correlations with comparable domains of the EORTC QLQ-C30 and CR29. Statistically significant associations were detected between LARS, COREFO, MSKCC-BFI scores and tumor distance and temporary stoma (P