G Protein-Coupled Receptor Kinases in the Inflammatory Response and Signaling.
G Protein-Coupled Receptor Kinases in the Inflammatory Response and Signaling.
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DOI：
10.1016/bs.ai.2017.05.003
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发表时间：
2017
影响因子：
--
通讯作者：
Parameswaran N
中科院分区：
文献类型：
--
作者：
Steury MD;McCabe LR;Parameswaran N
G蛋白偶联受体激酶（GRKs）是调节大量不同类别的G蛋白偶联受体（GPCR）的丝氨酸/苏氨酸激酶。通过GRK磷酸化和β-抑制蛋白募集，GPCR被脱敏并终止其信号。最近对这些激酶的研究已经将它们的作用从规范的GPCR调节扩展到包括通过磷酸化以及通过支架功能对非GPCR和非受体底物的非规范调节。由于这些和其他的调节作用，GRKs已被证明在各种生理和病理生理过程，包括趋化性，信号传导，迁移，炎症基因表达等的结果中发挥关键作用。这些蛋白质的功能多样，使它们成为治疗的热门靶点。这些激酶在炎症和炎性疾病中的作用是目前许多实验室正在进行的一个不断发展的研究领域。在这篇综述中，我们描述了目前的知识状态有关的各种GRKs在炎症和炎症性疾病中的作用。
G-protein coupled receptor kinases (GRKs) are serine/threonine kinases that regulate a large and diverse class of G-protein coupled receptors (GPCRs). Through GRK phosphorylation and β-arrestin recruitment GPCRs are desensitized and their signal terminated. Recent work on these kinases has expanded their role from canonical GPCR regulation to include non-canonical regulation of non-GPCR and non-receptor substrates through phosphorylation as well as via scaffolding functions. Due to these and other regulatory roles, GRKs have been shown to play a critical role in the outcome of a variety of physiological and pathophysiological processes including chemotaxis, signaling, migration, inflammatory gene expression, etc. This diverse set of functions for these proteins makes them popular targets for therapeutics. Role for these kinases in inflammation and inflammatory disease is an evolving area of research currently pursued in many laboratories. In this review, we describe the current state of knowledge on various GRKs pertaining to their role in inflammation and inflammatory diseases.
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G蛋白偶联受体激酶5的HIP磷酸化调节趋化因子受体CXCR4的内在化。
影响因子：
2.9
作者：
Barker, Breann L.;Benovic, Jeffrey L.
通讯作者：
Benovic, Jeffrey L.
DOI：
10.1073/pnas.95.6.2985
发表时间：
1998-03-17
影响因子：
11.1
作者：
Aragay, AM;Mellado, M;Mayor, F
通讯作者：
Mayor, F
影响因子：
4.8
作者：
Carman, CV;Lisanti, MP;Benovic, JL
通讯作者：
Benovic, JL
影响因子：
3.5
作者：
Ambrose, Christine;James, Marianne;Church, Deanne
通讯作者：
Church, Deanne
影响因子：
20.1
作者：
Brinks H;Boucher M;Gao E;Chuprun JK;Pesant S;Raake PW;Huang ZM;Wang X;Qiu G;Gumpert A;Harris DM;Eckhart AD;Most P;Koch WJ
通讯作者：
Koch WJ