Scalp topography of the auditory evoked K-complex in stage 2 and slow wave sleep
Scalp topography of the auditory evoked K-complex in stage 2 and slow wave sleep
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DOI：
10.1046/j.1365-2869.1999.00164.x
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发表时间：
1999-12-01
影响因子：
4.4
通讯作者：
Campbell, KB
中科院分区：
文献类型：
--
作者：
Cote, KA;De Lugt, DR;Campbell, KB
在NREM睡眠期间，在呈现外部刺激时，可能会引起非常大幅度的波形，称为K复合波。本研究比较了头皮分布的一个突出的负波峰值在约550毫秒和后来的正波峰值之间的900和1300毫秒在第2阶段和慢波睡眠（SWS）。9名受试者在实验室里度过了一个晚上。每隔15秒，他们被呈现80 dB SPL 2000 Hz听觉音调。从29个电极部位记录EEG，并以鼻子为参考。一个K-复合体引起的34%的试验在第2阶段和46%的试验在SWS。在330 ms处的负波峰值在引起K复合波的试验中比在不引起K复合波的试验中更大。大振幅N550在引起K复合体的试验中很容易观察到，但在不引起K复合体的试验中无法观察到。N550是双侧对称的，在第2阶段和SWS头皮的额中央区最大。它在乳突和下顶骨区域极性反转。N550的头皮分布在第2阶段和SWS之间存在显著差异。与SWS相比，第2阶段头皮顶叶和后下区的振幅下降更明显。后来的P900是最大的中央额区的头皮，也是双侧对称的。它显示了一个显着的急剧下降幅度在广泛的劣势地区在SWS。由于N550和P900的头皮图在2期和SWS中不同，因此它们的颅内来源也必须不同。
During NREM sleep a very large amplitude wave-form, known as the K-complex, may be elicited upon presentation of an external stimulus. The present study compared the scalp distribution of a prominent negative wave peaking at about 550 ms and a later positive wave peaking between 900 and 1300 ms in stage 2 and slow wave sleep (SWS). Nine subjects spent a single night in the laboratory. They were presented with an 80 dB SPL 2000 Hz auditory tone pip every 15 s. The EEG was recorded from 29 electrode sites and referenced to the nose. A K-complex was elicited on 34% of trials in stage 2 and on 46% of trials in SWS. A negative wave peaking at 330 ms was larger on trials in which the K-complex was elicited than on trials in which it was not. The large amplitude N550 was readily observable on trials in which the K-complex was elicited but could not be observed on trials in which it was not. The N550 was bilaterally symmetrical and was maximum over fronto-central areas of the scalp in both stage 2 and SWS. It inverted in polarity at the mastoid and inferior parietal regions. The scalp distribution of N550 significantly differed between stage 2 and SWS. It showed a sharper decline in amplitude over parietal and posterior-inferior areas of the scalp in stage 2 compared to SWS. A later P900 was maximum over centro-frontal areas of the scalp and was also bilaterally symmetrical. It showed a significantly sharper decline in amplitude over widespread inferior areas during SWS. Because the scalp maps of the N550 and P900 are different in stage 2 and SWS, their intracranial sources must also be different.