"Nonswellable" Hydrogel Without Mechanical Hysteresis
"Nonswellable" Hydrogel Without Mechanical Hysteresis
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DOI：
10.1126/science.1247811
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发表时间：
2014-02-21
期刊：
影响因子：
56.9
通讯作者：
Sakai, Takamasa
中科院分区：
文献类型：
--
作者：
Kamata, Hiroyuki;Akagi, Yuki;Sakai, Takamasa
水凝胶是一种三维聚合物网络，内部含有大量的水。某些水凝胶可以注入到溶液中，并以所需的形状转变为凝胶状态。尽管水凝胶具有潜在的生物医学应用，但由于所有传统的水凝胶在生理条件下都不可避免地发生膨胀，大大降低了其力学性能，因此水凝胶的使用受到了严重限制。我们报道了由亲水性聚合物和热响应性聚合物合成的可注射的“不可溶胀”水凝胶，其中两种独立发生的效应(膨胀和收缩)相互对立。这种水凝胶可以承受高达60兆帕斯卡的压应力，可以无滞后地拉伸七倍以上。我们的结果表明，溶胀的抑制有助于保持水凝胶在生理条件下的力学性能。
Hydrogels are three-dimensional polymer networks that contain a large amount of water inside. Certain hydrogels can be injected in solution and transformed into the gel state with the required shape. Despite their potential biomedical applications, the use of hydrogels has been severely limited because all the conventional hydrogels inevitably "swell" under physiological conditions, which drastically degrades their mechanical properties. We report the synthesis of injectable "nonswellable" hydrogels from hydrophilic and thermoresponsive polymers, in which two independently occurring effects (swelling and shrinking) oppose each other. The hydrogels can endure a compressive stress up to 60 megapascals and can be stretched more than sevenfold without hysteresis. Our results demonstrate that the suppression of swelling helps retain the mechanical properties of hydrogels under physiological conditions.