Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development.
Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development.
复制标题
DOI：
10.1007/s12576-015-0416-1
复制
发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Yamagishi S
中科院分区：
文献类型：
--
作者：
Akita T;Kumada T;Yoshihara S;Egea J;Yamagishi S
我们复杂的思想和行为是基于我们复杂的神经系统的奇迹般的发展，在这个系统中，许多不同类型的蛋白质和信号级联以时间和空间有序的方式受到调节。在这里，我们回顾了我们最近从一般的细胞现象和分子，如容量调节的阴离子通道，细胞内的钙离子和环核苷酸信号，Npas4转录因子和轴突引导分子的Flt家族来把握神经系统发育的原理的尝试。我们还提供了一个例子，说明相同的FLRT家族也可能调节血管网络的发育。这篇综述的目的是为了解神经系统和血管系统发育的复杂性开辟新的前景。
Our sophisticated thoughts and behaviors are based on the miraculous development of our complex nervous network system, in which many different types of proteins and signaling cascades are regulated in a temporally and spatially ordered manner. Here we review our recent attempts to grasp the principles of nervous system development in terms of general cellular phenomena and molecules, such as volume-regulated anion channels, intracellular Ca2+ and cyclic nucleotide signaling, the Npas4 transcription factor and the FLRT family of axon guidance molecules. We also present an example illustrating that the same FLRT family may regulate the development of vascular networks as well. The aim of this review is to open up new vistas for understanding the intricacy of nervous and vascular system development.