Immune responses to Toxoplasma gondii in the gut
Immune responses to Toxoplasma gondii in the gut
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DOI：
10.1016/s0171-2985(99)80063-1
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发表时间：
1999-12-01
期刊：
影响因子：
2.8
通讯作者：
Liesenfeld, O
中科院分区：
文献类型：
--
作者：
Liesenfeld, O
弓形虫是孕妇、新生儿和免疫功能低下的宿主的重要致病原因。感染I：弓形虫自然通过进食含有包囊的生或未煮熟的肉类或通过接触含有卵囊的猫粪便而发生。因此，肠道似乎是寄生虫入侵的地方。由于免疫活性宿主的急性感染通常不会被注意到，因此没有关于人类急性感染期间肠道参与的信息。然而，在这种疾病的小鼠模型中，感染的急性期也没有得到详细的研究。在这份报告中，概述了目前关于弓形虫感染初期的知识。本文综述了有关该寄生虫的侵袭和扩散以及在肠道内引起的免疫反应的研究结果。讨论了小鼠的遗传背景和性别对诱导局部免疫反应的影响，以及不同剂量和品系的寄生虫的作用。最后，对肠道病理学在不同动物物种中的发展以及肠道在人类疾病中的作用进行了综述。
Toxoplasma gondii is an important cause of disease, in pregnant women, newborns and immunocompromised hosts. Infection with I:gondii naturally occurs through ingestion of raw or undercooked meat containing cysts or through contact with cat feces containing oocysts. The intestine thus appears to be the site of invasion of the parasite. Since acute infection in immunocompetent hosts usually goes unnoticed, no information is available regarding the involvement of the intestine during acute infection in humans. However, in murine models of the disease the acute phase of infection has not been investigated in detail as well. In this report, an overview of the current knowledge regarding the initial phase of infection with T. gondii is given. Results of studies focussing on invasion and dissemination of the parasite and the immune responses elicited in the intestine are reviewed. The impact on the induction of local immune responses of the genetic background and sex of mice as well as the role of different doses and strains of the parasite are discussed. Finally, reports on the development of intestinal pathology in different animal species and the involvement of the intestine in human disease are reviewed.