The affinity of bone to hydroxyapatite and alumina in experimentally induced osteoporosis.
The affinity of bone to hydroxyapatite and alumina in experimentally induced osteoporosis.
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DOI：
10.1016/s0883-5403(89)80022-1
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发表时间：
1989-09-01
期刊：
影响因子：
--
通讯作者：
Sugioka, Y
中科院分区：
文献类型：
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作者：
Hayashi, K;Uenoyama, K;Sugioka, Y
通过切断坐骨神经建立大鼠骨质疏松症模型，研究了羟基磷灰石(HAP)和氧化铝(Al_2O_3)对骨质的影响。分别于坐骨神经切除16周和32周后，将羟基磷灰石和氧化铝植入大鼠胫骨。将骨与羟基磷灰石的反应与其与生物惰性氧化铝的反应作为对照进行比较。结果用亲和力指数(没有中间纤维膜的直接与种植体相对的骨的长度/骨-种植体界面的总长度x 100%)进行分析。在坐骨神经切除后16周的大鼠中，植入羟基磷灰石和氧化铝后24周的指标值分别为96.9+/-2.4%(N=8)和75.2+/-22.2%(N=8)。术后24周，坐骨神经切断32周，HAP指数为97.2+/-2.6%(N=12)，Al_2O_3指数为86.9+/-15.4%(N=12)。与氧化铝相比，骨对羟基磷灰石具有更高的亲和力(P<0.05)。
The authors studied how bone reacts to hydroxyapatite (HAP) and alumina (Al2O3) in osteoporosis experimentally induced in a rat animal model by resection of the sciatic nerve. Sixteen and 32 weeks after resection of the sciatic nerve, implants of HAP and Al2O3 were inserted into rat tibias. The reaction of bone to HAP was compared with its reaction to Al2O3, which is bioinert, as a control. The results were analyzed using the affinity index (the length of bone directly opposed to the implant without an intervening fibrous membrane/total length of the bone-implant interface x 100%). In the rats left for 16 weeks after resection of the sciatic nerve the index values 24 weeks after insertion of HAP and Al2O3 were 96.9 +/- 2.4% (N = 8) and 75.2 +/- 22.2% (N = 8), respectively. The index value of HAP was 97.2 +/- 2.6% (N = 12) and of Al2O3 was 86.9 +/- 15.4% (N = 12) at 24 weeks after insertion, when the rats were first left for 32 weeks, after sciatic nerve resection. Bone was demonstrated to have a superior affinity to HAP, compared with Al2O3 (P less than .05).