Analysis of fMRI and finger tracking training in subjects with chronic stroke
Analysis of fMRI and finger tracking training in subjects with chronic stroke
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DOI：
10.1093/brain/awf091
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发表时间：
2002-04-01
期刊：
影响因子：
14.5
通讯作者：
Ugurbil, K
中科院分区：
文献类型：
--
作者：
Carey, JR;Kimberley, TJ;Ugurbil, K
采用功能磁共振成像（fMRI）对10例慢性脑卒中患者进行手指运动跟踪训练前后的手部运动恢复和皮层重组进行了研究。受试者被随机分为实验组和对照组。实验组在不同条件下使用目标波形进行18-20次手指跟踪训练。对照组在对照组结束后进行交叉治疗。为了与健康人群进行比较，还研究了9名老年女性；然而，井龄控制组在控制期后没有交叉。因变量包括Box和Block评分，用于测量可握握能力（仅卒中受试者），跟踪准确性评分和使用功能磁共振成像（fMRI）对活跃皮质区域的量化。在跟踪测试中，受试者在电脑屏幕上跟踪一个正弦波目标，同时进行双亲双亲的食指的伸展和弯曲运动。用4特斯拉磁铁从受试者的额叶和顶叶采集脑功能图像。感兴趣的区域包括感觉运动皮层（SMC）、初级运动区（M1）、初级感觉区（S1）、运动前皮层（PMC）和辅助运动区（SMA）。采用双样本t检验对所有脑卒中患者和所有健康老年人进行前测比较。用配对t检验分析受试者从前测到后测的变化。P
Hand movement recovery and cortical reorganization were studied in 10 subjects with chronic stroke using functional MRI (fMRI) before and after training with an intensive finger movement tracking programme. Subjects were assigned randomly to a treatment or control group. The treatment group received 18-20 sessions of finger tracking training using target waveforms under variable conditions. The control group crossed over to receive the same treatment after the control period. For comparison with a healthy population, nine well elderly females were also studied; however, the well elderly controls did not cross over after the control period. The dependent variables consisted of a Box and Block score to measure prehensile ability (subjects with stroke only), a tracking accuracy score and quantification of active cortical areas using fMRI. For the tracking tests, the subjects tracked a sine wave target on a computer screen with extension and flexion movements of the paretic index finger. Functional brain images were collected from the frontal and parietal lobes of the subject with a 4 tesla magnet. Areas of interest included the sensorimotor cortex (SMC), primary motor area (M1), primary sensory area (S1), premotor cortex (PMC) and supplementary motor area (SMA). Comparison between all subjects with stroke and all well elderly subjects at pre-test was analysed with two-sample t-tests. Change from pre-test to post-test within subjects was analysed with paired t-tests. Statistical significance was set at P