Histopathological findings following SARS-CoV-2 infection with and without treatment-Report of three autopsies
Histopathological findings following SARS-CoV-2 infection with and without treatment-Report of three autopsies
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DOI：
10.1007/s00194-020-00408-x
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发表时间：
2020-07-06
期刊：
影响因子：
0.5
通讯作者：
Kernbach-Wighton, G.
中科院分区：
文献类型：
--
作者：
Dettmeyer, R.;Lasczkowski, G.;Kernbach-Wighton, G.
根据目前的知识水平，在具有致命病程的SARS-CoV-2感染病例中，通常累及几个内脏器官。病理变化主要见于肺组织，但也有关于肾脏、肝脏和心肌样本中SARS-CoV-2感染引起的直接或间接（组织学）病理变化的报告。使用常规组织学染色比较三例与SARS-CoV-2感染相关的男性致死病例，发现部分相同的结果，可以解释疾病的时间顺序和病理生理学。其中两名男子在重症监护室接受了侵入性通气，一名男子在国内隔离8天后未经治疗死亡。必须考虑到可能与SARS-CoV-2相关的广泛发现。
According to the current state of knowledge, several internal organs are usually involved in cases of SARS-CoV-2 infections with a fatal course. Pathological changes are primarily found in lung tissues but there are also reports concerning direct or indirect (histo)pathological changes due to SARS-CoV-2 infections in samples from the kidneys, liver and myocardium. Comparing three fatal cases associated with SARS-CoV-2 infections in men using conventional histological staining, there were partly identical findings that enabled interpretations with respect to the chronology and pathophysiology of the disease. Of the men two were invasively ventilated in the intensive care unit and one man died after 8 days in domestic quarantine without treatment. A wide spectrum of findings potentially associated with SARS-CoV-2 must be taken into account.