Childhood Asthma and Parental Antidepressant Use in a Nationwide Danish Cohort.
Childhood Asthma and Parental Antidepressant Use in a Nationwide Danish Cohort.
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儿童哮喘和父母抗抑郁药的使用在丹麦全国队列。
DOI：
10.2147/jaa.s421169
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发表时间：
2023
影响因子：
3.2
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中科院分区：
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儿童哮喘与照顾者抑郁有关，而照顾者抑郁又与哮喘控制不良有关。尽管社会人口学风险因素与哮喘儿童的父母抑郁有关，但这些因素对免费获得全民医疗保健环境中的照顾者抑郁的贡献尚不清楚。2015年，在丹麦全国范围内兑换吸入性皮质类固醇的2-17岁儿童队列中，对儿童哮喘与父母抗抑郁药使用之间的相关性进行了调查。与在兄弟姐妹数量、居住地、收入和教育方面1：1匹配的对照家庭相比，估计了使用抗抑郁药物的几率。在28,595名积极治疗哮喘儿童的家庭中，12%的母亲和6.2%的父亲接受了抗抑郁治疗，而对照组的这一比例分别为9.3%和5.3%(p<；0.001)。儿童哮喘与父母使用抗抑郁药的几率增加有关(OR 1.29(1.23-1.35))，即使在调整了父母哮喘因素后也是如此。较差的哮喘控制，但不是较高的哮喘严重程度，与较高的抗抑郁药使用几率(1.43(1.31-1.56))相关。与对照组相比，有两个或多个孩子的哮喘家庭的OR(1.42(1.29~1.56))高于独生子女(OR 1.27(1.21~1.34))。较低的社会经济地位与父母使用抗抑郁药物有关。在丹麦的一个队列中，照顾者抑郁在母亲中比在父亲中更普遍，并与儿童哮喘控制不良有关。照顾者中抗抑郁药物的使用与家庭哮喘总负担有关，并且与社会经济地位无关。
Paediatric asthma is associated with caregiver depression, which in turn is associated with poor asthma control. Although sociodemographic risk factors are associated with parental depression among children with asthma, the contribution of these factors to caregiver depression in free-to-access universal healthcare settings is unknown. The association between childhood asthma and parental antidepressant use was investigated in a Danish nationwide cohort of children aged 2–17 years that redeemed inhaled corticosteroids in 2015. The odds of antidepressant use were estimated in comparison to control families that were matched 1:1 on the number of siblings, residence, income, and education. Among the families of 28,595 children with actively treated asthma, 12% of mothers and 6.2% of fathers were on antidepressant therapy, compared to 9.3% and 5.3% in controls (p<0.001). Paediatric asthma was associated with increased odds of parental antidepressant use (OR 1.29 (1.23–1.35)), even after adjusting for parental asthma. Poor asthma control, but not higher asthma severity, was associated with higher odds of antidepressant use (1.43 (1.31–1.56)). Compared with the controls, families with two or more children with asthma had higher OR (1.42 (1.29–1.56)) than those with a single child (OR 1.27 (1.21–1.34)). Low socioeconomic status was associated with parental antidepressant use. Caregiver depression in a Danish cohort is more prevalent among mothers than among fathers and is associated with poor asthma control in children. Antidepressant use among caregivers was associated with total family asthma burden and was independent of socioeconomic status.