Epithelial-to-mesenchymal transition in prostate cancer: paradigm or puzzle?
Epithelial-to-mesenchymal transition in prostate cancer: paradigm or puzzle?
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DOI：
10.1038/nrurol.2011.85
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发表时间：
2011-06-21
期刊：
影响因子：
--
通讯作者：
Henry MD
中科院分区：
文献类型：
--
作者：
Nauseef JT;Henry MD
前列腺癌的致命后果与其转移到其他器官部位有关。上皮-间质转化（Epithelial-to-mesenchymal transition， EMT）作为一种解释癌症进展过程中侵袭性和转移性行为的概念范式受到了相当大的关注。EMT是一个正常的生理过程，由上皮细胞转化为具有间充质特征的细胞。有人提出，在癌细胞从原发器官转移到继发器官的过程中，EMT被癌细胞所吸收，但这在多大程度上概括了生理性EMT仍不确定。然而，有充分的证据表明，emt样状态发生在前列腺癌的进展和转移中，并可能导致前列腺癌的进展和转移，因此已成为一个非常活跃的研究领域。在此，我们回顾了这些证据，并探讨了旨在更好地定义EMT在前列腺癌中的作用和机制的最新研究。虽然在人类前列腺癌中仍缺乏类似生理性EMT的明确证据，但这一领域的研究为研究转移、治疗耐药性和预后生物标志物等长期困扰我们的问题提供了新的途径。
The lethal consequences of prostate cancer are related to its metastasis to other organ sites. Epithelial-to-mesenchymal transition (EMT) has received considerable attention as a conceptual paradigm to explain invasive and metastatic behavior during cancer progression. EMT is a normal physiologic process by which cells of epithelial origin convert into cells bearing mesenchymal characteristics. It has been proposed that EMT is co-opted by cancer cells during their metastatic dissemination from a primary organ to secondary sites, but the extent to which this recapitulates physiologic EMT remains uncertain. However, there is ample evidence that EMT-like states occur in, and may contribute to, prostate cancer progression and metastasis, and so has become a very active area of research. Here we review this evidence and explore recent studies that have aimed to better define the role and mechanisms of EMT in prostate cancer. While definitive evidence of something akin to physiologic EMT is still lacking in human prostate cancer, this area of research has nonetheless provided new avenues of investigation into the longstanding puzzles of metastasis, therapeutic resistance, and prognostic biomarkers.
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