DEVELOPMENT OF ENDOCOCHLEAR POTENTIAL AND ITS NEGATIVE COMPONENT IN MOUSE COCHLEA
DEVELOPMENT OF ENDOCOCHLEAR POTENTIAL AND ITS NEGATIVE COMPONENT IN MOUSE COCHLEA
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DOI：
10.1016/0378-5955(95)00133-x
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发表时间：
1995-09-01
期刊：
影响因子：
2.8
通讯作者：
MORIMITSU, T
中科院分区：
文献类型：
--
作者：
SADANAGA, M;MORIMITSU, T
本实验观察了正常ICR小鼠耳蜗基底回和第二回耳蜗内电位（EP）和负电位（-EP）随年龄的变化。基底回的EP在出生后5至17天（DAB）之间发育。基弯的-EP在11 DAB时达到成熟水平，在12至16 DAB之间进一步增加其绝对值，然后在20 DAB时再次恢复到成熟水平。第二回的EP和-EP的发育过程与基回的发育过程相似，但在细节上每天有几毫伏的差异。结果表明，缺氧时+ EP和-EP的发育过程是不同的，测定了每只动物缺氧时-EP达到最低值的时间，并计算了EP下降的速率。EP下降速率在10 DAB上迅速增加，几乎与EP开始突然增加的当天一致。虽然EP下降的速率受几个过程的影响，但这一结果表明，血管纹对缺氧的敏感性可能与EP的发展平行发展。
The chronological developmental processes of endocochlear potential (EP) and negative endocochlear potential (-EP) were investigated as a function of age from birth in the basal and second cochlear turns in normal ICR-strain mice. The EP of the basal turn developed between 5 and 17 days after birth (DAB). The -EP of the basal turn attained to its mature level on 11 DAB and it increased its absolute value further between 12 and 16 DAB and then, recovered to its mature level again on 20 DAB. The developmental processes of EP and -EP of the second turn followed similar courses to these of the basal turn although they were several millivolts different on each day in detail. The results suggest that the developmental processes of the + EP and the -EP are different.The time of reaching minimum -EP during anoxia were measured and the rate of EP decline were calculated on each animal. The rate of EP decline increased rapidly on 10 DAB, almost coinciding the day which EP began to increase abruptly. Although the rate of EP decline is influenced by several processes, this result showed one of the possibility that the sensitivity of the stria vascularis to hypoxia may develop parallel to the development of the EP.