Effect of alteration of rat hepatic mixed-function oxidase (MFO) activity on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Effect of alteration of rat hepatic mixed-function oxidase (MFO) activity on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
复制标题
改变大鼠肝脏混合功能氧化酶（MFO）活性对2,3,7,8-四氯二苯并-对二恶英（TCDD）毒性的影响。
DOI：
10.1016/0041-008x(78)90113-8
复制
发表时间：
1978
影响因子：
3.8
通讯作者：
Robert A. Neal
中科院分区：
文献类型：
--
作者：
Patrick W. Beatty;William K. Vaughn;Robert A. Neal
本文研究了肝脏混合功能氧化酶(MFO)酶系活性变化对2，3，7，8-四氯二苯并对二恶英(TCDD)毒性的影响。这些实验表明，自然发生的大鼠肝脏MFO活性的年龄和性别差异与这些动物TCDD的20天半数致死量(LD50)呈负相关。还观察了肝脏MFO酶系统的诱导剂和抑制剂对TCDD大鼠20天半数致死量(LD50)的影响。在所有病例中，TCDD给药时肝脏MFO系统的活性与TCDD的20天半数致死量(LD50)测定的毒性之间呈负相关。
The effect of alteration of the activity of the hepatic mixed-function oxidase (MFO) enzyme systems on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats has been examined. These experiments have indicated the naturally occurring age and sex-related differences in hepatic MFO activity in rats are inversely correlated with the 20-day LD50 of TCDD in these animals. The effect of administering inducers and inhibitors of the hepatic MFO enzyme systems on the 20-day LD50 of TCDD in rats has also been examined. In all cases there was an inverse relationship between the activity of the hepatic MFO system at the time of TCDD administration and the toxicity of TCDD as determined by the 20-day LD50.