The evolution of eukaryotic cells from the perspective of peroxisomes
The evolution of eukaryotic cells from the perspective of peroxisomes
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DOI：
10.1002/bies.201400151
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发表时间：
2015-02-01
期刊：
影响因子：
4
通讯作者：
Maier, Uwe-G.
中科院分区：
文献类型：
--
作者：
Bolte, Kathrin;Rensing, Stefan A.;Maier, Uwe-G.
脂肪酸的β-氧化和活性氧的解毒通常被认为是过氧化物酶体的基本功能。此外，这些途径可能是在真核生物进化过程中有利于选择该隔室的驱动力。在这里，我们进行了系统发育分析的酶参与β-氧化的脂肪酸在细菌，真核生物，和古细菌。这意味着四种酶中有三种来自α-变形菌。通过将酶的历史整合到真核细胞起源的对比模型中，我们得出结论，过氧化物酶体很可能是在古细菌宿主细胞中获得线粒体后以非共生方式进化的。
Beta-oxidation of fatty acids and detoxification of reactive oxygen species are generally accepted as being fundamental functions of peroxisomes. Additionally, these pathways might have been the driving force favoring the selection of this compartment during eukaryotic evolution. Here we performed phylogenetic analyses of enzymes involved in beta-oxidation of fatty acids in Bacteria, Eukaryota, and Archaea. These imply an alpha-proteobacterial origin for three out of four enzymes. By integrating the enzymes' history into the contrasting models on the origin of eukaryotic cells, we conclude that peroxisomes most likely evolved non-symbiotically and subsequent to the acquisition of mitochondria in an archaeal host cell.