Japanese Burkitt's lymphoma: clinicopathological review of 14 cases.
Japanese Burkitt's lymphoma: clinicopathological review of 14 cases.
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日本伯基特淋巴瘤：14 例临床病理学回顾。
DOI：
10.1093/oxfordjournals.jjco.a038904
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发表时间：
1983
影响因子：
2.4
通讯作者：
I. Miyoshi
中科院分区：
文献类型：
--
作者：
I. Miyoshi
本文回顾了14例日本Burkitt淋巴瘤的临床病理特征。5名患者年龄在12岁或以下。6名患者出现腹部肿块，5名患者出现颌骨肿瘤。12名患者在最初诊断时(4名患者)或后来的病程中(8名患者)表现出血液和/或骨髓受累。尽管进行了联合化疗，大多数患者仍有较快的临床病程。所有患者的恶性细胞均为B细胞表型，13例表面免疫球蛋白为IgM，1例为免疫球蛋白。两名患者的肿瘤对EB病毒确定的核抗原呈阳性，而其他所有患者的肿瘤中都缺乏这种抗原。染色体分析显示9例患者为标准t(8；14)易位，2例为14q+染色体，无供体染色体，2例为变异型t(2；8)易位，1例为t(8；22)易位。
The clinicopathological features of 14 Japanese patients with Burkitt's lymphoma (seven studied by us and seven reported by others) are reviewed. Five patients were 12 years of age or younger. Six patients presented with abdominal masses and five with jaw tumors. Twelve patients manifested blood and/or marrow involvement at the time of initial diagnosis (four patients) or later in the course of the disease (eight patients). Most of the patients had a rapid clinical course in spite of combination chemotherapy. The malignant cells from all patients exhibited a B-cell phenotype; the surface immunoglobulin was IgM in 13 and IgG in one. Two patients had tumors positive for Epstein-Barr virus-determined nuclear antigen while all the others lacked this antigen in their tumors. Chromosome analysis revealed a standard t(8;14) translocation in nine patients, a 14q+ chromosome without an identifiable donor chromosome in two and variant translocations t(2;8) in two and t(8;22) in one.