Bafilomycins Produced in Culture by Streptomyces spp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy
Bafilomycins Produced in Culture by Streptomyces spp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy
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DOI：
10.1021/np900632r
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发表时间：
2010-03-01
影响因子：
5.1
通讯作者：
Andersen, Raymond J.
中科院分区：
文献类型：
--
作者：
Carr, Gavin;Williams, David E.;Andersen, Raymond J.
五种新的巴非霉素。F（1）~ J（5），从两种链霉菌的实验室培养物中分离得到。通过对不列颠哥伦比亚省近海沉积物的光谱数据分析和模型化合物的合成，确定了它们的结构。在显微镜和生物化学测定中，新的巴非霉素F（1）、G（2）、H（3）和J（5）单独与几种共同存在的已知类似物显示出对自噬的有效抑制。巴夫洛霉素F（1）中存在的硫代吗啉酮片段以前未在天然产物中发现。
Five new bafilomycins. F (1) to J (5), have been isolated from laboratory Cultures of two Streptomyces spp. obtained front marine sediments collected in British Columbia, and their Structures have been elucidated by detailed analysis of spectroscopic data and the synthesis of model compounds. The new bafilomycins F (1), G (2), H (3), and J (5) alone with several co-occurring known analogues showed potent inhibition of autophagy in microscopy and biochemical assays. The thiomorpholinone fragment present in bafilomycin F (1) has not previously been found in a natural product.