WATER/N-OCTANOL PARTITION-COEFFICIENTS OF 1,2-DITHIOLE-3-THIONES

WATER/N-OCTANOL PARTITION-COEFFICIENTS OF 1,2-DITHIOLE-3-THIONES
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DOI:
10.1002/jps.2600840914
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发表时间:
1995-09-01
影响因子:
3.8
通讯作者:
BURGOT, JL
BURGOT, JL
中科院分区:
医学3区
文献类型:
--
作者:
BONA, M;BOUDEVILLE, P;BURGOT, JL

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Water/n-octanol partition coefficients (log P) for 33 1,2-dithiole-3-thiones and for 18 1,2-dithiol-3-ones were determined by RP-HPLC measurement of the concentration of the solute in aqueous solution after equilibrium. Depending on the nature of the substituents (alkyl or aryl) and their position(s) (4, 5, or both) on the dithiole nucleus, some peculiar behavior's were revealed. Therefore, different fragmental constants containing the 1,2-dithiole-3-thione nucleus were inferred in order to calculate in a complementary work, a priori, the log P values of new dithiolethiones and dithiolones