Perinatal hypothyroidism decreases hippocampal mossy fiber zinc density in rats.
Perinatal hypothyroidism decreases hippocampal mossy fiber zinc density in rats.
复制标题
围产期甲状腺功能减退症会降低大鼠海马苔藓纤维锌密度。
DOI：
10.1159/000126092
复制
发表时间：
1992
影响因子：
4.1
通讯作者：
Kasarskis,EJ
中科院分区：
文献类型：
--
作者：
Savage,DD;Otero,MA;Montano,CY;Razani-Boroujerdi,S;Paxton,LL;Kasarskis,EJ
观察围产期甲状腺功能减退对大鼠海马区苔藓纤维锌密度的影响。从妊娠第18天开始，给定时妊娠的SD大鼠喂食含有0.02%丙基硫氧嘧啶(PTU)或赋形剂的水，直到出生后第31天断奶。与未处理对照组相比，31天龄PTU处理组大鼠海马CA3层透明层背侧和腹侧海马区苔藓纤维锌密度均降低75%。围产期甲状腺功能减退并未改变海马区组织锌浓度，表明PTU引起的苔藓纤维锌浓度降低不是海马区锌浓度降低的结果。在120天龄，即停止PTU治疗3个月后，PTU治疗组大鼠海马区苔藓纤维锌密度与对照组相比仍显著降低33-45%。这些数据表明，围产期甲状腺功能减退会导致海马区苔藓状纤维锌密度的长期下降。
The effect of perinatal hypothyroidism on hippocampal mossy fiber zinc density was examined in rats. Timed pregnant Sprague-Dawley rat dams were given water containing either 0.02% propylthiouracil (PTU) or vehicle from gestational day 18 until their litters were weaned on postnatal day 31. Hippocampal mossy fiber zinc density was reduced by 75% in both the dorsal and ventral hippocampal formation CA3 stratum lucidum region of 31-day-old PTU-treated rats compared to untreated controls. Perinatal hypothyroidism did not alter hippocampal tissue zinc concentration, indicating that the PTU-induced reduction in mossy fiber zinc was not a consequence of reduced hippocampal zinc concentration. At 120 days of age, 3 months after discontinuation of PTU treatment, hippocampal mossy fiber zinc density remained significantly reduced by 33-45% in PTU-treated rats compared to control. These data indicate that perinatal hypothyroidism causes a long-lasting reduction in hippocampal mossy fiber zinc density.