Vasohibin-1 Is a Poor Prognostic Factor of Ovarian Carcinoma
Vasohibin-1 Is a Poor Prognostic Factor of Ovarian Carcinoma
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DOI：
10.1620/tjem.243.107
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发表时间：
2017-10-01
影响因子：
2.2
通讯作者：
Shiota, Mitsuru
中科院分区：
文献类型：
--
作者：
Sano, Rikiya;Kanomata, Naoki;Shiota, Mitsuru
Vasohibin-1（VASH 1）是血管内皮生长因子（vascular endothelial growth factor，VEGF）诱导血管内皮细胞（vascular endothelial cells，ECs）新生的负反馈抑制因子。VASH 1不仅在正常组织的内皮细胞中表达，而且在恶性肿瘤周围的内皮细胞中也有表达。在恶性肿瘤中，VASH 1作为预后预测标志物也受到关注。本研究的目的是探讨卵巢癌中VASH 1表达与血管相关因素及各种临床病理结果之间的相关性。回顾性分析58例卵巢癌患者的临床资料。免疫组化法检测VASH 1和其他血管相关因子（CD 31作为微血管密度（MVD）的标志物，VEGF受体2（VEGFR 2），D2-40作为淋巴管密度的标志物）以及Ki 67（作为癌细胞增殖的标志物）的表达模式。我们研究了免疫组化表达与总生存率之间的相关性。妇产科联合会（FIGO）阶段之间的VASH 1表达模式显着不同。VASH 1阳性血管数与MVD（Speaman相关系数（rho）为0.51，p < 0.001）、VEGFR 2阳性血管数（rho = 0.61，p < 0.001）和Ki 67百分比（rho = 0.28，p = 0.034）呈显著正相关。考克斯单变量分析显示，VASH 1高表达组（> 14.6支血管/mm 2）在I-III期是一个预后因素（HR = 3.3，95%CI = 0.4-8.4; p = 0.013）。我们的研究结果表明，卵巢癌中VASH 1的表达与血管相关因子和Ki 67的表达显着相关。我们认为VASH 1是卵巢癌的一个预后标志物。
Vasohibin-1 (VASH1) is an identified negative feedback inhibitor of angiogenesis induced by vascular endothelial growth factor (VEGF) in vascular endothelial cells (ECs). Expression of VASH1 has been reported not only in ECs of normal tissue, but also in ECs surrounding malignant tumors. In malignant tumors, VASH1 is also gaining attention as a prognosis prediction marker. The aim of this study is to investigate the correlation between VASH1 expression and vascular-related factors and various clinicopathological outcomes in clinical cases of ovarian carcinoma. We retrospectively analyzed clinical records of 58 patients with ovarian carcinoma. The expression patterns of VASH1 and other vascular related factors (CD31 as markers of microvessel density (MVD), VEGF receptor type 2 (VEGFR2), D2-40 as markers of lymphovessel density), and Ki67 (as proliferation markers of cancer cells) were examined immunohistochemically. We studied the correlation between immunohistochemical expression and overall survival. VASH1 expression pattern significantly differed between Federation of Obstetrics and Gynecology (FIGO) Stages. Numbers of VASH1-positive vessels had a significant positive correlation with MVD (Speaman's correlation coefficient (rho) was 0.51, p < 0.001), VEGFR2-positive vessels (rho = 0.61, p < 0.001), and percentage of Ki67 (rho = 0.28, p = 0.034). The Cox univariable analyses revealed that the group of high VASH1 expression (> 14.6 vessels per mm(2)) at Stages I-Ill is a prognostic factor (HR = 3.3, 95%Cl = 0.4-8.4; p = 0.013). Our results indicate that VASH1 expression in ovarian carcinoma is significantly associated with vascular-related factors and Ki67 expression. We propose that VASH1 is a prognostic marker in ovarian carcinoma.