Insights Into Leukocyte Trafficking in Inflammatory Arthritis - Imaging the Joint.
Insights Into Leukocyte Trafficking in Inflammatory Arthritis - Imaging the Joint.
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DOI：
10.3389/fcell.2021.635102
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发表时间：
2021
影响因子：
5.5
通讯作者：
McGettrick HM
中科院分区：
文献类型：
--
作者：
Manning JE;Lewis JW;Marsh LJ;McGettrick HM
白细胞的不适当积累和激活是免疫介导的炎症性疾病（IMIDs）的共同病理特征，如类风湿关节炎（RA）和银屑病关节炎（PsA）。因此，细胞积累是治疗干预的一个有吸引力的目标。然而，迄今为止，调节白细胞进入和退出关节的尝试被证明是不成功的，这表明我们的知识仍然存在差距。技术进步现在允许通过关节炎关节或体外关节结构实时跟踪白细胞的运动。将这项技术与白细胞与邻近细胞的细胞组成、位置和相互作用的分析相结合，增加了我们对关节炎关节中白细胞病理积累的时间动力学和分子机制的理解。在这篇综述中，我们探讨了目前对炎症性关节炎中导致白细胞不适当运输的机制的理解，以及这些机制如何随着疾病进展而演变。此外，我们强调了人类和小鼠关节成像的进展，以及多细胞离体关节结构，这些都导致了我们目前的知识库。
The inappropriate accumulation and activation of leukocytes is a shared pathological feature of immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Cellular accumulation is therefore an attractive target for therapeutic intervention. However, attempts to modulate leukocyte entry and exit from the joint have proven unsuccessful to date, indicating that gaps in our knowledge remain. Technological advancements are now allowing real-time tracking of leukocyte movement through arthritic joints or in vitro joint constructs. Coupling this technology with improvements in analyzing the cellular composition, location and interactions of leukocytes with neighboring cells has increased our understanding of the temporal dynamics and molecular mechanisms underpinning pathological accumulation of leukocytes in arthritic joints. In this review, we explore our current understanding of the mechanisms leading to inappropriate leukocyte trafficking in inflammatory arthritis, and how these evolve with disease progression. Moreover, we highlight the advances in imaging of human and murine joints, along with multi-cellular ex vivo joint constructs that have led to our current knowledge base.
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影响因子：
1.2
作者：
Campbell-Thompson, Martha L.;Heiple, Tiffany;Schneider, Lynda
通讯作者：
Schneider, Lynda
影响因子：
82.9
作者：
Chimen M;McGettrick HM;Apta B;Kuravi SJ;Yates CM;Kennedy A;Odedra A;Alassiri M;Harrison M;Martin A;Barone F;Nayar S;Hitchcock JR;Cunningham AF;Raza K;Filer A;Copland DA;Dick AD;Robinson J;Kalia N;Walker LSK;Buckley CD;Nash GB;Narendran P;Rainger GE
通讯作者：
Rainger GE
影响因子：
5.5
作者：
Buckley, Christopher D.;Ross, Ewan A.;Rainger, G. Ed
通讯作者：
Rainger, G. Ed
影响因子：
5.6
作者：
Damerau A;Gaber T
通讯作者：
Gaber T
影响因子：
27.4
作者：
Behrens, Frank;Himsel, Andrea;Radeke, Heinfried H.
通讯作者：
Radeke, Heinfried H.