Synthesis of Tetracyclic Tetrahydro‐β‐carbolines by Acid‐Promoted One‐Pot Sequential Formation of C−C and C−N Bonds
Synthesis of Tetracyclic Tetrahydro‐β‐carbolines by Acid‐Promoted One‐Pot Sequential Formation of C−C and C−N Bonds
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DOI：
10.1002/ajoc.201600349
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发表时间：
2016-11
影响因子：
2.7
通讯作者：
V. Nagaraju;Dalovai Purnachander;K. Goutham;S. Suresh;B. Sridhar;Galla V. Karunakar
中科院分区：
文献类型：
--
作者：
V. Nagaraju;Dalovai Purnachander;K. Goutham;S. Suresh;B. Sridhar;Galla V. Karunakar
提出了一种有效的合成四环四氢碳氢化合物的方法，该方法以对甲磺酸为介导剂，通过-氨基酮与乙酰二甲酸酯的反应合成了四环四氢碳啉。在一锅反应条件下，合成了高官能化的四环四氢碳啉衍生物，其中先后发生了两个C-C键和一个C-N键的形成。
An efficient synthetic protocol was developed for the formation of tetracyclic tetrahydro--carbolines using p-TSA mediated reaction of -enaminones and acetylenedicarboxylates. Highly functionalized tetracyclic tetrahydro--carboline derivatives were synthesized in one pot reaction conditions, where two C-C and one C-N bond formations have occurred, sequentially.