Long-term test-retest reliability of functional MRI in a classification learning task
Long-term test-retest reliability of functional MRI in a classification learning task
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DOI：
10.1016/j.neuroimage.2005.08.010
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发表时间：
2006-02-01
期刊：
影响因子：
5.7
通讯作者：
Poldrack, RA
中科院分区：
文献类型：
--
作者：
Aron, AR;Gluck, MA;Poldrack, RA
功能磁共振成像被广泛用于成像心理过程的神经关联，以及这些大脑过程如何随着学习、发育和神经精神障碍的变化而变化。为了解释成像信号随时间的变化，例如，在患者研究中，必须首先建立FMR1的长期可靠性。在这里，8名健康的成年受试者被扫描了两次，间隔一年，同时执行一项已知的激活额纹状体回路的分类学习任务。我们表明，在两个时间点，行为表现和额纹状体激活在群体水平上是高度一致的。此外，类内相关系数(ICCs)在行为和功能激活方面都很高，它衡量了不同时间点受试者之间的相关程度。在通过学习招募的网络内的ICC显著高于该网络外的ICC。我们的结论是，fMRI具有较高的长期重测信度，适合作为脑发育和神经退行性变的生物标志物。(C)2005年，爱思唯尔公司出版。
Functional MRI is widely used for imaging the neural correlates of psychological processes and how these brain processes change with learning, development and neuropsychiatric disorder. In order to interpret changes in imaging signals over time, for example, in patient studies, the long-term reliability of fMR1 must first be established. Here, eight healthy adult subjects were scanned on two sessions,1 year apart, while performing a classification learning task known to activate frontostriatal circuitry. We show that behavioral performance and frontostriatal activation were highly concordant at a group level at both time-points. Furthermore, intra-class correlation coefficients (ICCs), which index the degree of correlation between subjects at different time-points, were high for behavior and for functional activation. ICC was significantly higher within the network recruited by learning than outside that network. We conclude that FMRI can have high long-term test-retest reliability, making it suitable as a biomarker for brain development and neurodegeneration. (c) 2005 Published by Elsevier Inc.