Does vitamin D stop inpatients falling? A randomised controlled trial
Does vitamin D stop inpatients falling? A randomised controlled trial
复制标题
DOI：
10.1093/ageing/afm087
复制
发表时间：
2007-09-01
期刊：
影响因子：
6.7
通讯作者：
Potter, Jan
中科院分区：
文献类型：
--
作者：
Burleigh, Elizabeth;Mccoll, John;Potter, Jan
Background vitamin D deficiency is common in older people and may increase risk of falls and fracture. Hospital inpatients are at particular risk of falling. Previous studies suggest that vitamin D improves neuromuscular function and reduces falls.Objective to determine whether routine supplementation with vitamin D plus calcium reduces numbers of fallers and falls in a cohort of hospital admissions while they are inpatients.Design randomised, double-blind, controlled study.Participants two hundred and five acute admissions > 65 years to a geriatric medical unit.Methods patients were randomised to intervention of daily vitamin D 800 iu plus calcium 1,200 mg or control group of daily calcium 1,200 mg, until discharge or death. Results baseline characteristics were similar in both groups with a median age 84 years and a median length of stay = 30 days (IQR 14.75-71.00). In a pre-selected sub-group (54/205 participants), median admission vitamin D level = 22.00 nmol/l (IQR 15.00-30.50). This did not significantly increase in the treatment versus control group. Median study drug adherence = 88%, with no significant difference between study groups (Mann-Whitney: P = 0.711). Although there were fewer fallers in the vitamin D cohort, this did not reach statistical significance (vitamin D: calcium = 36: 45 fallers; RR 0.82 (CI 0.59-1.16). Neither the mean number of falls (vitamin D: calcium = 1.040: 1.155; Mann-Whitney P = 0.435) or time to first fall (Log-rank test P = 0.377) differed between groups.Conclusions in a population of geriatric hospital inpatients, vitamin D did not reduce the number of fallers. Routine supplementation cannot be recommended to reduce falls in this group.
