Exosomes and Atherogenesis.
Exosomes and Atherogenesis.
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外泌体和动脉粥样硬化形成。
DOI：
10.3389/fcvm.2021.738031
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发表时间：
2021
影响因子：
3.6
通讯作者：
Feng J
中科院分区：
文献类型：
--
作者：
Lin B;Yang J;Song Y;Dang G;Feng J
心肌梗死和缺血性卒中是全球死亡的主要原因。动脉粥样硬化是其共同的病理基础。已知动脉粥样硬化的特征在于内皮活化/损伤、炎性免疫细胞和富含脂质的泡沫细胞的积累，随后是动脉粥样硬化斑块的发展。动脉粥样硬化的发病机制中，内皮细胞、平滑肌细胞、巨噬细胞、T淋巴细胞、B淋巴细胞、泡沫细胞和血小板等均参与动脉粥样硬化的发生。外泌体作为天然的纳米载体和细胞间信使，在细胞间通讯调控中发挥着重要作用。在生理或病理条件下，外泌体可以将其货物（包括供体细胞特异性蛋白质、脂质和核酸）递送至靶细胞，这进而影响靶细胞的功能。本文就来源于不同细胞类型的exosome在动脉粥样硬化中的病理生理意义及其在临床诊断和治疗中的应用进行综述。
Myocardial infarction and ischemic stroke are the leading causes of mortality worldwide. Atherosclerosis is their common pathological foundation. It is known that atherosclerosis is characterized by endothelial activation/injury, accumulation of inflammatory immune cells and lipid-rich foam cells, followed by the development of atherosclerotic plaque. Either from arterial vessel wall or blood circulation, endothelial cells, smooth muscle cells, macrophages, T-lymphocytes, B-lymphocytes, foam cells, and platelets have been considered to contribute to the pathogenesis of atherosclerosis. Exosomes, as natural nano-carriers and intercellular messengers, play a significant role in modulation of cell-to-cell communication. Under physiological or pathological conditions, exosomes can deliver their cargos including donor cell-specific proteins, lipids, and nucleic acids to target cells, which in turn affect the function of the target cells. In this review, we will describe the pathophysiological significance of various exosomes derived from different cell types associated with atherosclerosis, and the potential applications of exosome in clinical diagnosis and treatment.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
外泌体作为帕金森氏病疗法的药物。
DOI：
10.1016/j.jconrel.2015.03.033
发表时间：
2015-06-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Haney MJ;Klyachko NL;Zhao Y;Gupta R;Plotnikova EG;He Z;Patel T;Piroyan A;Sokolsky M;Kabanov AV;Batrakova EV
通讯作者：
Batrakova EV
影响因子：
6.7
作者：
Aharon, Anat;Tamari, Tal;Brenner, Benjamin
通讯作者：
Brenner, Benjamin
影响因子：
7.5
作者：
Basavaraj, Manjunath Goolyam;Sovershaev, Mikhail A.;Hansen, John-Bjarne
通讯作者：
Hansen, John-Bjarne
来自成熟树突状细胞的外泌体通过膜 TNF-α 介导的 NF-κ B 途径增加内皮炎症和动脉粥样硬化
影响因子：
5.3
作者：
Gao W;Liu H;Yuan J;Wu C;Huang D;Ma Y;Zhu J;Ma L;Guo J;Shi H;Zou Y;Ge J
通讯作者：
Ge J