Diverse cell signaling events modulated by perlecan.
Diverse cell signaling events modulated by perlecan.
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DOI：
10.1021/bi8013938
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发表时间：
2008-10-28
期刊：
影响因子：
2.9
通讯作者：
Iozzo, Renato V.
中科院分区：
文献类型：
--
作者：
Whitelock, John M.;Melrose, James;Iozzo, Renato V.
串珠素是一种普遍存在的细胞周围蛋白聚糖，理想地用于介导控制迁移、增殖和分化的细胞信号传导事件。它对生长因子信号传导的控制通常涉及与共价偶联到蛋白质核心的N-末端的硫酸乙酰肝素链的相互作用。然而，这种模块化蛋白质核心也以相对高的亲和力与许多生长因子和表面受体结合，从而稳定细胞-基质连接。这篇综述将集中在串珠素/生长因子的相互作用，并描述了我们的理解，这种高度保守的蛋白聚糖在发展，癌症生长和血管生成的最新进展。将探索串珠素的促血管生成能力，其涉及响应于结合的生长因子的增殖和迁移信号，以及由称为内排斥素的C-末端结构域和控制细胞粘附至细胞外基质的整合素之间的相互作用产生的抗血管生成信号。这两个有点截然相反的作用将讨论新的数据出现在各个领域的收敛串珠素作为一个关键的调节细胞生长和血管生成。
Perlecan is a ubiquitous pericellular proteoglycan ideally placed to mediate cell signaling events controlling migration, proliferation and differentiation. Its control of growth factor signaling usually involves interactions with the heparan sulfate chains covalently coupled to the protein core’s N-terminus. However, this modular protein core also binds with relatively high affinity to a number of growth factors and surface receptors, thereby stabilizing cell-matrix links. This review will focus on perlecan/growth factor interactions and describe recent advances in our understanding of this highly-conserved proteoglycan during development, cancer growth and angiogenesis. The pro-angiogenic capacities of perlecan that involve proliferative and migratory signals in response to bound growth factors will be explored, as well as the anti-angiogenic signals resulting from interactions between the C-terminal domain known as endorepellin and integrins that control cell adhesion to the extracellular matrix. These two somewhat diametrically-opposed roles will be discussed in light of new data emerging from various fields which converge on perlecan as a key regulator of cell growth and angiogenesis.
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影响因子：
2.7
作者：
Chen, E;Stringer, SE;Ekker, SC
通讯作者：
Ekker, SC
影响因子：
5.2
作者：
Kadenhe-Chiweshe, Angela;Papa, Joey;Yamashiro, Darrell J.
通讯作者：
Yamashiro, Darrell J.
影响因子：
64.5
作者：
Hilgenberg, LGW;Su, HL;Smith, MA
通讯作者：
Smith, MA
影响因子：
20.3
作者：
Bix, Gregory;Iozzo, Rex A.;Iozzo, Renato V.
通讯作者：
Iozzo, Renato V.
DOI：
10.1093/jnci/djj441
发表时间：
2006-11-15
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Bix, Gregory;Castello, Remedios;Iozzo, Renato V.
通讯作者：
Iozzo, Renato V.