Interplay Between Plasmodium Infection and Resistance to Insecticides in Vector Mosquitoes
Interplay Between Plasmodium Infection and Resistance to Insecticides in Vector Mosquitoes
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DOI：
10.1093/infdis/jiu276
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发表时间：
2014-11-01
影响因子：
6.4
通讯作者：
Cohuet, Anna
中科院分区：
文献类型：
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作者：
Alout, Haoues;Yameogo, Bienvenue;Cohuet, Anna
尽管杀虫剂抗药性在流行病学上具有重要意义，但人们对杀虫剂抗药性对病媒-寄生虫相互作用和疟疾传播的影响知之甚少。在这里，我们探讨了疟原虫感染的影响，对杀虫剂的耐药性水平二氯二苯三氯乙烷（DDT）在现场捕获的冈比亚按蚊狭义纯合子的kdr突变。结果表明，kdr纯合子蚊子，感染性血液喂养比蚊子喂养的非感染性血液在动合子发育（第1天后的血餐）和卵囊成熟（第7天后的血餐），但不是在子孢子入侵的唾液腺更容易受到滴滴涕。恶性疟原虫感染似乎通过降低kdr纯合子A。严格意义上的冈比亚人在接触滴滴涕后存活。这些结果表明疟原虫感染和携带抗疟原虫等位基因的蚊子对杀虫剂的敏感性之间存在相互作用。我们讨论了这一发现的病媒控制效果。
Despite its epidemiological importance, the impact of insecticide resistance on vector-parasite interactions and malaria transmission is poorly understood. Here, we explored the impact of Plasmodium infection on the level of insecticide resistance to dichlorodiphenyltrichloroethane (DDT) in field-caught Anopheles gambiae sensu stricto homozygous for the kdr mutation. Results showed that kdr homozygous mosquitoes that fed on infectious blood were more susceptible to DDT than mosquitoes that fed on noninfectious blood during both ookinete development (day 1 after the blood meal) and oocyst maturation (day 7 after the blood meal) but not during sporozoite invasion of the salivary glands. Plasmodium falciparum infection seemed to impose a fitness cost on mosquitoes by reducing the ability of kdr homozygous A. gambiae sensu stricto to survive exposure to DDT. These results suggest an interaction between Plasmodium infection and the insecticide susceptibility of mosquitoes carrying insecticide-resistant alleles. We discuss this finding in relation to vector control efficacy.