A novel coaptation plate device for functional mitral regurgitation: an in vitro study.
A novel coaptation plate device for functional mitral regurgitation: an in vitro study.
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用于功能性二尖瓣反流的新型接合板装置：体外研究。
DOI：
10.1007/s10439-014-1065-x
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发表时间：
2014
影响因子：
3.8
通讯作者：
Gao,Bo
中科院分区：
文献类型：
--
作者：
He,Zhaoming;Zhang,Kailiang;Gao,Bo
提出了一种新型二尖瓣修复装置——接合板（CP）来治疗功能性二尖瓣反流。本研究的目的是测试 CP 在功能性二尖瓣反流体外模型中的功效。将十个新鲜猪二尖瓣安装在左心模拟器中，通过环形扩张和不对称或对称乳头肌（PM）位移来模拟二尖瓣反流。制作了刚性和弹性CP并将其安装在反流二尖瓣的孔口中。在植入 CP 之前和之后测量了静水条件下的稳态流量泄漏和脉动流量下的回流体积。在不对称 PM 位移中，刚性和弹性 CP 分别将二尖瓣反流体积分数从 60.5 ± 11.4 减少到 35 ± 11.6 和 36.5 ± 9.9%。对称性 PM 位移中的二尖瓣反流远低于非对称性 PM 位移中的二尖瓣反流，并且在植入任一 CP 后都没有显着减少。总之，刚性和弹性 CP 均有效，并且在减少功能性二尖瓣反流方面没有差异。 CP 不会加重二尖瓣接合，可用作预防方法。
A novel mitral valve repair device, coaptation plate (CP), was proposed to treat functional mitral regurgitation. The objective of this study was to test efficacy of the CP in anin vitromodel of functional mitral regurgitation. Ten fresh porcine mitral valves were mounted in a left heart simulator, Mitral regurgitation was emulated by means of annular dilatation, and the asymmetrical or symmetrical papillary muscles (PM) displacement. A rigid and an elastic CPs were fabricated and mounted in the orifice of regurgitant mitral valves. Steady flow leakage in a hydrostatic condition and regurgitant volume in a pulsatile flow were measured before and after implantation of the CPs. The rigid and elastic CPs reduced mitral valve regurgitant volume fraction from 60.5 ± 11.4 to 35 ± 11.6 and 36.5 ± 9.9%, respectively, in the asymmetric PM displacement. Mitral regurgitation was much lower in the symmetric PM displacement than in the asymmetric PM displacement, and was not significantly reduced after implantation of either CP. In conclusion, both the rigid and elastic CPs are effective and have no difference in reduction of functional mitral regurgitation. The CP does not aggravate mitral valve coaptation and may be used as a preventive way.