Effects of microplastics on the uptake, distribution and biotransformation of chiral antidepressant venlafaxine in aquatic ecosystem.
Effects of microplastics on the uptake, distribution and biotransformation of chiral antidepressant venlafaxine in aquatic ecosystem.
复制标题
微塑料对水生生态系统中手性抗抑郁药文拉法辛的吸收、分布和生物转化的影响。
DOI：
10.1016/j.jhazmat.2018.07.016
复制
发表时间：
2018-10
影响因子：
13.6
通讯作者：
Wang Yujue
中科院分区：
文献类型：
--
作者：
Qu Han;Ma Ruixue;Wang Bin;Zhang Yizhe;Yin Lina;Yu Gang;Deng Shubo;Huang Jun;Wang Yujue
在本研究中，我们研究了手性抗抑郁药文拉法辛（VFX）在微塑料（MP）存在下的实验室规模的水生态系统中的对映体选择性环境行为。为了确定MP的生物累积、分布和代谢以及对水生生态系统的影响，建立了水-沉积物、水-浮萍（Lemna.minor）、水-泥鳅（Misgurnus.anguillicaudatus）和水-沉积物-浮萍-泥鳅生态系统，并将其暴露于文拉法辛和两个水平的微塑料中90天。不同生态系统对VFX的去除率在58%~ 96%之间，在S-对映体优先富集的水-沉积物-小龙虾-泥鳅复合生态系统中，VFX的降解速度明显加快。主要代谢产物O-去甲基文拉法辛（O-DVFX）也观察到在生态系统中，显示出类似的对映体选择性。当暴露于50 mg L− 1微塑料时，沉积物和泥鳅（M.anguillicaudatus）中的文拉法辛含量显著高于1 mg L− 1微塑料处理，并观察到O-DVFX在泥鳅中的累积增强。本研究首次评估了文拉法辛和微塑料在模拟水生微宇宙中的联合效应，有助于深入了解手性污染物和微塑料的潜在生态影响，并在未来更准确地评估其环境风险。
In this study, we investigated the enantioselective environmental behaviors of the chiral antidepressant venlafaxine (VFX) in lab-scale aquatic ecosystems in the presence of microplastics (MPs). To determine the bioaccumulation, distribution, and metabolism as well as the effects of MPs on aquatic ecosystems, water-sediment, water-Lemna.minor(L.minor), water-Misgurnus.anguillicaudatus(M.anguillicaudatus), and water-sediment-L.minor-M.anguillicaudatusecosystems were set up and exposed to venlafaxine and two levels of microplastics over a 90-day period. The removal efficiencies of VFX ranged from 58 to 96% in different ecosystems, and VFX degraded significantly faster in the complex water-sediment-L.minor-M.anguillicaudatusecosystem with S-enantiomer preferentially enriched. The main metabolite O-desmethylvenlafaxine (O-DVFX) was also observed in ecosystems, displaying similar enantioselectivity. When exposed to 50 mg L−1of microplastics, the amount of venlafaxine in sediment and loach (M.anguillicaudatus) were significantly higher than that in the 1 mg L−1microplastics treatments, and enhanced accumulation of O-DVFX was observed in loach. The present study for the first time assessed the combined effects of venlafaxine and microplastics in simulated aquatic microcosms, which could help gain an insight into the potential ecological impacts of chiral pollutants and microplastic, and evaluate their environment risks more accurately in future.
登录
查看更多内容
影响因子：
11.4
作者：
Holly A. Rogers;T. S. Schmidt;Brittanie L Dabney;M. Hladik;B. Mahler;P. V. Van Metre
通讯作者：
Holly A. Rogers;T. S. Schmidt;Brittanie L Dabney;M. Hladik;B. Mahler;P. V. Van Metre
DOI：
10.1177/0973408215600602b
发表时间：
2015-09
期刊：
Journal of Education for Sustainable Development
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1515/dmdi-2013-0053
发表时间：
2014-09-01
期刊：
Drug Metabolism and Drug Interactions
影响因子：
--
作者：
Magalhaes, Paulo;Alves, Gilberto;Falcao, Amilcar
通讯作者：
Falcao, Amilcar
DOI：
10.1098/rstb.2008.0205
发表时间：
2009-07-27
影响因子：
6.3
作者：
Barnes, David K. A.;Galgani, Francois;Barlaz, Morton
通讯作者：
Barlaz, Morton
影响因子：
56.9
作者：
Jambeck, Jenna R.;Geyer, Roland;Law, Kara Lavender
通讯作者：
Law, Kara Lavender