Lymphoid hyperplasia of the colon and its association with underlying allergic airway diseases.
Lymphoid hyperplasia of the colon and its association with underlying allergic airway diseases.
复制标题
结肠淋巴增生及其与潜在过敏性气道疾病的关联。
DOI：
10.1007/s00384-015-2392-6
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Yamamoto K.
中科院分区：
文献类型：
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作者：
Iwamuro M;Hiraoka S;Okada H;Kawai Y;Miyabe Y;Takata K;Kawano S;Yamamoto K.
目的本研究的目的是确定下胃肠道淋巴增生的患病率及其在接受结肠镜检查的患者中的作用，特别关注任何过敏倾向。方法在尾道市立医院胃肠科进行的数据库检索发现了 7 名大肠（即盲肠、结肠和/或直肠）淋巴增生的患者。从临床记录中回顾性审查了每位患者进行的内窥镜、生物学和病理学检查以及过敏史的数据。结果患者（四名男性，三名女性）的中位年龄为 50 岁。盲肠(n=≥5)、升结肠(n=≥2)和横结肠(n=≥1)可见淋巴增生。 6 名患者 (85.7%) 患有过敏性气道疾病之一：花粉过敏性鼻结膜炎 (n= 3)、支气管哮喘 (n= 1)、婴儿哮喘 (n= 1) 或过敏性支气管炎 (n= 1)。还发现药物过敏（n= 3）和荨麻疹（n= 2）。所有七名患者均患有一种或多种过敏性疾病；然而，没有人有食物过敏史。过敏原血液检测显示，6 名患者（85.7%）对固有过敏原呈阳性反应，而只有 1 名患者对食物过敏原呈阳性反应。结论我们的结果表明，大肠淋巴增生可能与过敏性气道疾病有关，而不是与食物过敏有关；因此，它的存在可能有助于检测潜在气道高反应性的患者。
PurposeThe purpose of this study was to determine the prevalence of lymphoid hyperplasia in the lower gastrointestinal tract and its role in patients undergoing colonoscopic examinations, particularly focusing on any allergic predisposition.MethodsA database search performed at the Department of Gastroenterology at Onomichi Municipal Hospital identified seven patients with lymphoid hyperplasia in the large intestine (i.e., cecum, colon, and/or rectum). Data regarding the endoscopic, biological, and pathological examinations performed and the allergic histories for each patient were retrospectively reviewed from the clinical records.ResultsMedian age of the patients (four males, three females) was 50 years. Lymphoid hyperplasia was seen in the cecum (n= 5), ascending colon (n= 2), and transverse colon (n= 1). Six patients (85.7 %) had one of the allergic airway diseases: allergic rhinoconjunctivitis for pollen (n= 3), bronchial asthma (n= 1), infantile asthma (n= 1), or allergic bronchitis (n= 1). Drug allergy (n= 3) and urticaria (n= 2) were also found. All seven patients had one or more allergic diseases; however, none had a history of food allergy. Blood tests for allergens revealed that six patients (85.7 %) had positive reactions to inherent allergens, whereas only one patient had a positive reaction to food allergens.ConclusionsOur results indicate that lymphoid hyperplasia in the large intestine may be associated with allergic airway diseases rather than with food allergies; thus, its presence may be useful to detect patients with underlying airway hyperreactivity.